Difference between revisions of "Non-invasive breast carcinoma"

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===Microscopic===
===Microscopic===
Features:
Features:
*Cells cohesive.
*Architectural changes:
**No spaces in between.
**Equal spacing of cells - "cookie cutter" look.
*Cells spaced equally - "cookie cutter" look.
**Cells line-up along lumen/glandular spaces - form "Roman briges".
*Cells line-up along lumen/glandular spaces - form "Roman briges".
**Architecture suggestive of DCIS - see ''[[Subtypes of DCIS]]''
*Nuclear changes:
*Nuclear changes:
**Nuclear enlargement - at least 2-3x size of RBC - '''key feature'''.
**Nuclear enlargement - at least 2-3x size of RBC - '''key feature'''.
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*Apocrine changes of cytoplasm -- nuclei should be ~4x RBC for low grade, 5x RBC for high grade.<ref>URL: [http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html]. Accessed on: 4 August 2011.</ref>
*Apocrine changes of cytoplasm -- nuclei should be ~4x RBC for low grade, 5x RBC for high grade.<ref>URL: [http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html]. Accessed on: 4 August 2011.</ref>


====Subtypes====
====Subtypes of DCIS====
Subtypes are based on architecture:
Subtypes are based on architecture:
*Solid.
*Solid.
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