Difference between revisions of "Soft tissue lesions"
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m (→Molecular testing: gr.) |
m (→Vascular tumours: DDx of hyaline globs) |
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===Microscopic=== | ===Microscopic=== | ||
Features:<ref>Klatt. AOP P.23.</ref> | Features:<ref>Klatt. AOP P.23.</ref> | ||
*Vascular channels that anastomose. | *Vascular channels that anastomose - '''key feature'''. | ||
*+/-Nuclear atypia. | *+/-Nuclear atypia. | ||
*Hyaline globules - pale pink globs (that are paler than RBCs) - ''' | *Hyaline globules (intracytoplasmic)<ref name=pmid7528163>{{cite journal |author=del Rosario AD, Bui HX, Singh J, Ginsburg R, Ross JS |title=Intracytoplasmic eosinophilic hyaline globules in cartilaginous neoplasms: a surgical, pathological, ultrastructural, and electron probe x-ray microanalytic study |journal=Hum. Pathol. |volume=25 |issue=12 |pages=1283–9 |year=1994 |month=December |pmid=7528163 |doi= |url=}}</ref> - pale pink globs (that are paler than RBCs) - '''important feature'''. | ||
*+/-Hemosiderin deposits. | *+/-Hemosiderin deposits. | ||
DDx: | DDx: | ||
*Angiosarcoma (have many mitoses). | *Angiosarcoma (have many mitoses). | ||
Notes: | |||
*Hyaline globules have a DDx (hepatocellular carcinoma, lung adenocarcinoma, chondrosarcomas + others).<ref name=pmid7528163/> | |||
===IHC=== | ===IHC=== | ||
*CD31 +ve | *CD31 +ve. | ||
*CD34 +ve. | |||
*HHV-8 +ve. | |||
==Angiosarcoma== | ==Angiosarcoma== | ||
===General=== | |||
*Malignant tumour. | *Malignant tumour. | ||
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==Hemangioendothelioma== | ==Hemangioendothelioma== | ||
===General=== | |||
*Usually benign. | *Usually benign. | ||