Difference between revisions of "Endometrial carcinoma"

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==Subtypes==

They are commonly grouped based on clinicopathologic features:<ref name=pmid21309259>{{Cite journal | last1 = Lim | first1 = D. | last2 = Oliva | first2 = E. | title = Nonendometrioid endometrial carcinomas. | journal = Semin Diagn Pathol | volume = 27 | issue = 4 | pages = 241-60 | month = Nov | year = 2010 | doi = | PMID = 21309259 }}</ref>

#Type I:

#*Histologic types:

#**Endometrioid (most common).

#**Mucinous.

#*Clinical characteristics: premenopausal, estrogen excess.

#Group II:

#*Histologic types:

#**Serous carcinoma.

#**Clear cell carcinoma.

#*Clinical characteristics: postmenopausal, no estrogen excess, poor prognosis.

The most common as a list:

#Endometrioid - '''most common''', patient typically is 55-65 years old and obese.

#Serous - patients classically older than endometrioid subtype, arise in atrophic endometrium.

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Notes:

*Dyskeratosis = abnormal keratinization;<ref>[http://dictionary.reference.com/browse/dyskeratosis http://dictionary.reference.com/browse/dyskeratosis]</ref> classically have intensely eosinophilic cytoplasm +/- nuclear fragmentation ([http://dictionary.reference.com/browse/karyolysis?db=medical&q=karyolysis karyorrhexis]) - see: [http://www.drmihm.com/pictures/Figure%203.jpg several dyskeratotic cells].

[[Media:Example.ogg]]

==Grading (FIGO)==

*Based on gland formation & adjusted by nuclear pleomorphism:<ref>{{Ref PBoD|1087-8}}</ref><ref>URL: [http://www.pathologyoutlines.com/uterus.html#endometrialcarc http://www.pathologyoutlines.com/uterus.html#endometrialcarc].</ref><ref>URL: [http://www.emedicine.com/med/topic2832.htm http://www.emedicine.com/med/topic2832.htm].</ref><ref name=pmid12496701>{{cite journal |author=Ayhan A, Taskiran C, Yuce K, Kucukali T |title=The prognostic value of nuclear grading and the revised FIGO grading of endometrial adenocarcinoma |journal=Int. J. Gynecol. Pathol. |volume=22 |issue=1 |pages=71–4 |year=2003 |month=January |pmid=12496701 |doi= |url=}}</ref>

Difference between revisions of "Endometrial carcinoma"

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@@ Line 30: / Line 30: @@
 ==Subtypes==
+They are commonly grouped based on clinicopathologic features:<ref name=pmid21309259>{{Cite journal  | last1 = Lim | first1 = D. | last2 = Oliva | first2 = E. | title = Nonendometrioid endometrial carcinomas. | journal = Semin Diagn Pathol | volume = 27 | issue = 4 | pages = 241-60 | month = Nov | year = 2010 | doi =  | PMID = 21309259 }}</ref>
+#Type I:
+#*Histologic types:
+#**Endometrioid (most common).
+#**Mucinous.
+#*Clinical characteristics: premenopausal, estrogen excess.
+#Group II:
+#*Histologic types:
+#**Serous carcinoma.
+#**Clear cell carcinoma.
+#*Clinical characteristics: postmenopausal, no estrogen excess, poor prognosis.
+The most common as a list:
 #Endometrioid - '''most common''', patient typically is 55-65 years old and obese.
 #Serous - patients classically older than endometrioid subtype, arise in atrophic endometrium.
@@ Line 52: / Line 65: @@
 Notes:
 *Dyskeratosis = abnormal keratinization;<ref>[http://dictionary.reference.com/browse/dyskeratosis http://dictionary.reference.com/browse/dyskeratosis]</ref> classically have intensely eosinophilic cytoplasm +/- nuclear fragmentation ([http://dictionary.reference.com/browse/karyolysis?db=medical&q=karyolysis karyorrhexis]) - see: [http://www.drmihm.com/pictures/Figure%203.jpg several dyskeratotic cells].
+[[Media:Example.ogg]]
 ==Grading (FIGO)==
 *Based on gland formation & adjusted by nuclear pleomorphism:<ref>{{Ref PBoD|1087-8}}</ref><ref>URL: [http://www.pathologyoutlines.com/uterus.html#endometrialcarc http://www.pathologyoutlines.com/uterus.html#endometrialcarc].</ref><ref>URL: [http://www.emedicine.com/med/topic2832.htm http://www.emedicine.com/med/topic2832.htm].</ref><ref name=pmid12496701>{{cite journal |author=Ayhan A, Taskiran C, Yuce K, Kucukali T |title=The prognostic value of nuclear grading and the revised FIGO grading of endometrial adenocarcinoma |journal=Int. J. Gynecol. Pathol. |volume=22 |issue=1 |pages=71–4 |year=2003 |month=January |pmid=12496701 |doi= |url=}}</ref>