Difference between revisions of "Pediatric-type diffuse high-grade glioma"
Jump to navigation
Jump to search
Jensflorian (talk | contribs) (New category Pediatric-type diffuse high-grade glioma) |
Jensflorian (talk | contribs) (→Diffuse hemispheric glioma, H3 G34-mutant: fist data) |
||
| Line 26: | Line 26: | ||
==Diffuse hemispheric glioma, H3 G34-mutant== | ==Diffuse hemispheric glioma, H3 G34-mutant== | ||
* | * Diffusely infiltrating glioma in young adults and adolescents. | ||
* WHO CNS grade 4 neoplasm. | |||
* Up to 15% of all hemispheric pediatric gliomas. | |||
* Highly cellular tumor often with microvascular proliferation and necrosis. | |||
* May resemble embryonal tumours (important DDx). | |||
* IHC: MAP2+ve, TP53+ve, Olig2-ve, ATRX loss. | |||
* H3F3A G43R or G34V mutation present. | |||
==References== | ==References== | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Neuropathology tumours]] | [[Category:Neuropathology tumours]] | ||