Difference between revisions of "Molecular pathology"

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(→‎Molecular: make tables)
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===Tests===
===Tests===
Hereditary:
====Hereditary====
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
! Target
! Target
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| -
| -
|-
|-
|  
| RYR1
|  
| PCR & sequencing
| Malignant hyperthermia
| malignant hyperthermia
| anesthetics
| anesthetics
|-
|-
| several
| PCR & sequencing
| herediary [[amyloidosis]]
|  
|  
|-
| HBA
| PCR
| Alpha thalassemia
|  
|  
| Herediary [[amyloidosis]]
|}
|  
 
====[[Lymphoma]]====
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
! Target
! Technique
! Disease
! Notes
|-
| BCL2
| PCR
| follicular lymphoma vs. follicular hyperplasia
|
|-
| several
| Southern / PCR
| T cell neoplasia
|
|-
|-
|  
|  
| Southern / PCR
| B cell neoplasia
|  
|  
| Alpha thalassemia
|-
|  
| EBV
|
| PTLPD vs. rejection
|
|-
| HHV8
|
| HHV8 associated lymphomas (body cavity lymphoma, primary effusion lymphoma)
|
|}
|}


[[Lymphoma]]:
====Leukemia====
*Follicular lymphoma vs. follicular hyperplasia (BCL2).
*T cell neoplasia.
*B cell neoplasia.
*PTLPD vs. rejection.
*HHV associated lymphomas.
Leukemia:
*Several.
*Several.


Carcinoma:
====Carcinoma====
*Nasopharyngeal (EBV quantitation).
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
*HPV testing.
! Target
*Metastatic [[colorectal carinoma]].
! Technique
*Non small cell [[lung cancer]].
! Disease
*Papillary thyroid carcinoma.
! Notes
|-
| EBV quantitation
| PQ-PCR
| [[Nasopharyngeal carcinoma]]
|
|-
| HPV several
| PCR
| squamous cell carcinoma ([[cervix]])
|
|-
| KRAS, BRAF
| fluorescent RFLP, real time PCR, sequencing
| netastatic [[colorectal carinoma]]
|
|-
| EGRF
| fluorescent RFLP
| non small cell [[lung cancer]]
|
|-
| BRAF V600E
| ARMS
| [[papillary thyroid carcinoma]]
|
|}


Other:
====Other====
*Oligodendroglioma.
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
*Identity testing (15 STRs and amelogenin (XY) loci).
! Target
*Melanoma (KIT, BRAF).
! Technique
*[[Synovial sarcoma]].
! Disease
*Myeloproliferative disorders.
! Notes
*AML, mastocytosis, GIST.
|-
|
|
| [[oligodendroglioma]]
|
|-
|
| 15 STRs and amelogenin (XY) loci
| identity testing
|
|-
| KIT, BRAF
|
| [[malignant melanoma]]
|
|-
|
|
| [[synovial sarcoma]]
|
|-
|
|
| myeloproliferative disorders
|
|-
| KIT
| sequencing
| AML, mastocytosis, [[GIST]]
|
|}


==Cytogenetics==
==Cytogenetics==
Retrieved from "https://librepathology.org/wiki/Molecular_pathology"