Difference between revisions of "Medical liver disease"

Jump to navigation Jump to search
(→‎Hepatitis B: split out)
Line 154: Line 154:
==Hepatitis B==
==Hepatitis B==
:''Hepatitis B virus'', abbreviated ''HBV'', redirects here.
:''Hepatitis B virus'', abbreviated ''HBV'', redirects here.
===General===
{{Main|Hepatitis B}}
*May lead to [[hepatocellular carcinoma]] without [[cirrhosis]].
*High prevalence.
*Diagnosis is by serology.
*A vaccination is available and done routinely in a many jurisdictions.<ref>{{Cite journal  | last1 = Leuridan | first1 = E. | last2 = Van Damme | first2 = P. | title = Hepatitis B and the need for a booster dose. | journal = Clin Infect Dis | volume = 53 | issue = 1 | pages = 68-75 | month = Jul | year = 2011 | doi = 10.1093/cid/cir270 | PMID = 21653306 }}</ref>
 
Associated pathology:
*[[Polyarteritis nodosa]] (PAN).
*[[Membranoproliferative glomerulonephritis]].
*[[Membranous nephropathy]].
 
===Microscopic===
Features:
*Lobular inflammation - this is non-specific finding.
**Hepatocyte necrosis:
***Necrotic hepatocytes look a lot like neutrophils - however:
****Cytoplasm is more pink.
****Round apoptotic bodies.
*[[Ground glass hepatocytes]] - '''important'''.
 
DDx:
*[[Hepatitis C]].
*[[Autoimmune hepatitis]].
*[[Primary biliary cirrhosis]] without [[granulomas]].
*[[Drug-induced liver disease|Drug reaction]].
 
====Image====
<gallery>
Image:Ground_glass_hepatocytes_high_mag_cropped_2.jpg | GGH - high mag. (WC)
</gallery>
 
===IHC===
*[[Hepatitis B]] +ve.


==Hepatitis C==
==Hepatitis C==
Retrieved from "https://librepathology.org/wiki/Medical_liver_disease"