Difference between revisions of "Esophageal adenocarcinoma"

Line 104:

*COX-2 +ve.

*p16 +ve - but not that useful as it's frequently positive in the precursors.<ref name=pmid15617840>{{Cite journal | last1 = Hardie | first1 = LJ. | last2 = Darnton | first2 = SJ. | last3 = Wallis | first3 = YL. | last4 = Chauhan | first4 = A. | last5 = Hainaut | first5 = P. | last6 = Wild | first6 = CP. | last7 = Casson | first7 = AG. | title = p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations. | journal = Cancer Lett | volume = 217 | issue = 2 | pages = 221-30 | month = Jan | year = 2005 | doi = 10.1016/j.canlet.2004.06.025 | PMID = 15617840 }}</ref>

==Staging==

*The number of lymph nodes is important for [[staging]], as a small number may lead to stage migration (Will Rogers phenomenon); thus, the number of lymph nodes is often used as a [[quality]] measure.

*There is no established standard for esophageal cancer (as per UICC/AJCC staging), several studies give different numbers (18 lymph nodes Li ''et al.'',<ref name=pmid23124992>{{Cite journal | last1 = Li | first1 = Q. | last2 = Wu | first2 = SG. | last3 = Gao | first3 = JM. | last4 = Xu | first4 = JJ. | last5 = Hu | first5 = LY. | last6 = Xu | first6 = T. | title = Impact of esophageal cancer staging on overall survival and disease-free survival based on the 2010 AJCC classification by lymph nodes. | journal = J Radiat Res | volume = 54 | issue = 2 | pages = 307-14 | month = Mar | year = 2013 | doi = 10.1093/jrr/rrs096 | PMID = 23124992 }}</ref> 23 lymph nodes Peyre ''et al.''<ref name=pmid18936567>{{Cite journal | last1 = Peyre | first1 = CG. | last2 = Hagen | first2 = JA. | last3 = DeMeester | first3 = SR. | last4 = Altorki | first4 = NK. | last5 = Ancona | first5 = E. | last6 = Griffin | first6 = SM. | last7 = Hölscher | first7 = A. | last8 = Lerut | first8 = T. | last9 = Law | first9 = S. | title = The number of lymph nodes removed predicts survival in esophageal cancer: an international study on the impact of extent of surgical resection. | journal = Ann Surg | volume = 248 | issue = 4 | pages = 549-56 | month = Oct | year = 2008 | doi = 10.1097/SLA.0b013e318188c474 | PMID = 18936567 }}</ref>).

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Difference between revisions of "Esophageal adenocarcinoma"

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@@ Line 104: / Line 104: @@
 *COX-2 +ve.
 *p16 +ve - but not that useful as it's frequently positive in the precursors.<ref name=pmid15617840>{{Cite journal  | last1 = Hardie | first1 = LJ. | last2 = Darnton | first2 = SJ. | last3 = Wallis | first3 = YL. | last4 = Chauhan | first4 = A. | last5 = Hainaut | first5 = P. | last6 = Wild | first6 = CP. | last7 = Casson | first7 = AG. | title = p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations. | journal = Cancer Lett | volume = 217 | issue = 2 | pages = 221-30 | month = Jan | year = 2005 | doi = 10.1016/j.canlet.2004.06.025 | PMID = 15617840 }}</ref>
+==Staging==
+*The number of lymph nodes is important for [[staging]], as a small number may lead to stage migration (Will Rogers phenomenon); thus, the number of lymph nodes is often used as a [[quality]] measure.
+*There is no established standard for esophageal cancer (as per UICC/AJCC staging), several studies give different numbers (18 lymph nodes Li ''et al.'',<ref name=pmid23124992>{{Cite journal  | last1 = Li | first1 = Q. | last2 = Wu | first2 = SG. | last3 = Gao | first3 = JM. | last4 = Xu | first4 = JJ. | last5 = Hu | first5 = LY. | last6 = Xu | first6 = T. | title = Impact of esophageal cancer staging on overall survival and disease-free survival based on the 2010 AJCC classification by lymph nodes. | journal = J Radiat Res | volume = 54 | issue = 2 | pages = 307-14 | month = Mar | year = 2013 | doi = 10.1093/jrr/rrs096 | PMID = 23124992 }}</ref> 23 lymph nodes Peyre ''et al.''<ref name=pmid18936567>{{Cite journal  | last1 = Peyre | first1 = CG. | last2 = Hagen | first2 = JA. | last3 = DeMeester | first3 = SR. | last4 = Altorki | first4 = NK. | last5 = Ancona | first5 = E. | last6 = Griffin | first6 = SM. | last7 = Hölscher | first7 = A. | last8 = Lerut | first8 = T. | last9 = Law | first9 = S. | title = The number of lymph nodes removed predicts survival in esophageal cancer: an international study on the impact of extent of surgical resection. | journal = Ann Surg | volume = 248 | issue = 4 | pages = 549-56 | month = Oct | year = 2008 | doi = 10.1097/SLA.0b013e318188c474 | PMID = 18936567 }}</ref>).
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