Difference between revisions of "Neuromuscular pathology"
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*Ragged red fibres = mitochondrial pathology. | *Ragged red fibres = mitochondrial pathology. | ||
**Image: [http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q71-Ans.htm Ragged red fibres (ouhsc.edu)]. | **Image: [http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q71-Ans.htm Ragged red fibres (ouhsc.edu)]. | ||
*Rimmed vacuoles = [[inclusion body myositis]]. | *Vacuoles | ||
**Acid maltase positive = lysosomal vacuoles. | |||
**Rimmed vacuoles = [[inclusion body myositis]]. | |||
**Freezing artifacts (clear). | |||
*PAS +++ = [[glycogen storage disease]]. | *PAS +++ = [[glycogen storage disease]]. | ||
* | *Nemaline rods = [[nemaline myopathy]] | ||
**Image: [http://commons.wikimedia.org/w/index.php?title=File:Biopsy nemaline myopathy gomori.jpg] | |||
*Cores - central pale area along length of fibres in NADH stain = central core disease. | |||
**Image: [http://commons.wikimedia.org/w/index.php?title=File:Central core disease NADH stain.jpg]. | |||
Others: | Others: | ||
*Target fibre - "hole in middle of myofibres" = neurogenic. | *Target fibre - "hole in middle of myofibres" = neurogenic. | ||
**Images: [http://commons.wikimedia.org/w/index.php?title=File:Denervation_atrophy_-_very_high_mag.jpg Target fibres - very high mag. (WC)], [http://commons.wikimedia.org/wiki/File:Denervation_atrophy_-_sdh_-_very_high_mag.jpg Target fibres - SDH stain - very high mag. (WC)]. | **Images: [http://commons.wikimedia.org/w/index.php?title=File:Denervation_atrophy_-_very_high_mag.jpg Target fibres - very high mag. (WC)], [http://commons.wikimedia.org/wiki/File:Denervation_atrophy_-_sdh_-_very_high_mag.jpg Target fibres - SDH stain - very high mag. (WC)]. | ||
* | *Regenerative fibres = large nuclei, basophilic cytoplasm (incr. protein synthesis, incr. RNA). | ||
===Approach=== | ===Approach=== | ||