Difference between revisions of "IDH-1"
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Jensflorian (talk | contribs) (IDH1 mutation specific antibody) |
Jensflorian (talk | contribs) (→Positive staining: pic update) |
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==Positive staining== | ==Positive staining== | ||
*Cytoplasmic<ref>{{Cite journal | last1 = Capper | first1 = D. | last2 = Weissert | first2 = S. | last3 = Balss | first3 = J. | last4 = Habel | first4 = A. | last5 = Meyer | first5 = J. | last6 = Jäger | first6 = D. | last7 = Ackermann | first7 = U. | last8 = Tessmer | first8 = C. | last9 = Korshunov | first9 = A. | title = Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. | journal = Brain Pathol | volume = 20 | issue = 1 | pages = 245-54 | month = Jan | year = 2010 | doi = 10.1111/j.1750-3639.2009.00352.x | PMID = 19903171 }}</ref> | *Cytoplasmic<ref>{{Cite journal | last1 = Capper | first1 = D. | last2 = Weissert | first2 = S. | last3 = Balss | first3 = J. | last4 = Habel | first4 = A. | last5 = Meyer | first5 = J. | last6 = Jäger | first6 = D. | last7 = Ackermann | first7 = U. | last8 = Tessmer | first8 = C. | last9 = Korshunov | first9 = A. | title = Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. | journal = Brain Pathol | volume = 20 | issue = 1 | pages = 245-54 | month = Jan | year = 2010 | doi = 10.1111/j.1750-3639.2009.00352.x | PMID = 19903171 }}</ref> | ||
** Does not stain endothelial cells and inflammatory cells. | |||
<gallery> | <gallery> | ||
File:IDH1_GBM_20x.jpg | IDH-1 (R132H) in a secondary glioblastoma | File:IDH1_GBM_20x.jpg | IDH-1 (R132H) in a secondary glioblastoma | ||
File:IDH1R132H oligoastrocytoma.jpg | IDH-1 in a oliogoastrocytoma grade II | |||
File:Neuropathology case IX.jpg | Absence of IDH-1 in a primary glioblastoma | |||
</gallery> | </gallery> | ||