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Difference between revisions of "Gestational trophoblastic disease"
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Gestational trophoblastic disease (view source)
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*p57(KIP2) - the gene is strongly paternally imprinted and the paternal copy is inactived; its expression is from the maternal gene. | *p57(KIP2) - the gene is strongly paternally imprinted and the paternal copy is inactived; its expression is from the maternal gene. | ||
**Complete moles lacks the maternal genome; thus, p57(KIP2) immunostaining is absent.<ref name=pmid15754295>{{cite journal |author=Merchant SH, Amin MB, Viswanatha DS, Malhotra RK, Moehlenkamp C, Joste NE |title=p57KIP2 immunohistochemistry in early molar pregnancies: emphasis on its complementary role in the differential diagnosis of hydropic abortuses |journal=Hum. Pathol. |volume=36 |issue=2 |pages=180–6 |year=2005 |month=February |pmid=15754295 |doi=10.1016/j.humpath.2004.12.007 |url=}}</ref> | **Complete moles lacks the maternal genome; thus, p57(KIP2) immunostaining is absent.<ref name=pmid15754295>{{cite journal |author=Merchant SH, Amin MB, Viswanatha DS, Malhotra RK, Moehlenkamp C, Joste NE |title=p57KIP2 immunohistochemistry in early molar pregnancies: emphasis on its complementary role in the differential diagnosis of hydropic abortuses |journal=Hum. Pathol. |volume=36 |issue=2 |pages=180–6 |year=2005 |month=February |pmid=15754295 |doi=10.1016/j.humpath.2004.12.007 |url=}}</ref> | ||
**Memory device: '''''p'''57 is '''p'''ositive in '''p'''artial moles''. | **Memory device - '''3 Ps''': '''''p'''57 is '''p'''ositive in '''p'''artial moles''; '''3''' = triploid. | ||
===Cytogenetics=== | ===Cytogenetics=== | ||