Difference between revisions of "Traditional serrated adenoma"
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| Micro = ectopic crypt foci (ECF), serrated, eosinophilic cytoplasm, villous-like architecture, "pine cone, fernlike, stellate pit pattern" | | Micro = ectopic crypt foci (ECF), serrated, eosinophilic cytoplasm, villous-like architecture, "pine cone, fernlike, stellate pit pattern" | ||
| Subtypes = With and without high grade dysplasia, mixed with other types of polyps | | Subtypes = With and without high grade dysplasia, mixed with other types of polyps | ||
| LMDDx = [[villous adenoma]], [[ | | LMDDx = [[villous adenoma]], [[hyperplastic polyp]], [[sessile serrated adenoma]] | ||
| Stains = | | Stains = | ||
| IHC = CK20 in the eosinophilic cells, absent in ECF; Ki67 (MIB1) stains ECF and absent in eosinophilic cells, MUC2+, MUC5CA+, MUC6-; In areas of dysplasia TP53+, nuclear B-catenin+; p16+ in late dysplasia | | IHC = CK20 in the eosinophilic cells, absent in ECF; Ki67 (MIB1) stains ECF and absent in eosinophilic cells, MUC2+, MUC5CA+, MUC6-; In areas of dysplasia TP53+, nuclear B-catenin+; p16+ in late dysplasia | ||
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*Villous-like architecture. | *Villous-like architecture. | ||
DDx: | DDx:<ref>URL: [http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/differential-diagnosis.html http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/differential-diagnosis.html]. Accessed on: 28 May 2015.</ref> | ||
*[[Villous adenoma]]. | *[[Villous adenoma]]. | ||
*[[Hyperplastic polyp]]. | |||
*[[Sessile serrated adenoma]]. | |||
===Images=== | ===Images=== | ||