Difference between revisions of "Seminoma"
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| Micro = fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus), lymphocytic infiltrate (common), +/-[[syncytiotrophoblast]]s (rare), +/-granulomas (uncommon) | | Micro = fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus), lymphocytic infiltrate (common), +/-[[syncytiotrophoblast]]s (rare), +/-granulomas (uncommon) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[embryonal carcinoma]], [[ITGCN]], [[mixed germ cell tumour]], granulomatous orchitis | | LMDDx = [[embryonal carcinoma]], [[ITGCN]], [[mixed germ cell tumour]], [[granulomatous orchitis]] | ||
| Stains = | | Stains = | ||
| IHC = OCT3 +ve, CD117 +ve, CD30 -ve | | IHC = OCT3 +ve, CD117 +ve, CD30 -ve | ||
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*[[Mixed germ cell tumour]]. | *[[Mixed germ cell tumour]]. | ||
*[[Choriocarcinoma]] - esp. if (multinucleated) syncytiotrophoblasts are present.<ref name=pmid157614>{{Cite journal | last1 = Hedinger | first1 = C. | last2 = von Hochstetter | first2 = AR. | last3 = Egloff | first3 = B. | title = Seminoma with syncytiotrophoblastic giant cells. A special form of seminoma. | journal = Virchows Arch A Pathol Anat Histol | volume = 383 | issue = 1 | pages = 59-67 | month = Jul | year = 1979 | doi = | PMID = 157614 }}</ref> | *[[Choriocarcinoma]] - esp. if (multinucleated) syncytiotrophoblasts are present.<ref name=pmid157614>{{Cite journal | last1 = Hedinger | first1 = C. | last2 = von Hochstetter | first2 = AR. | last3 = Egloff | first3 = B. | title = Seminoma with syncytiotrophoblastic giant cells. A special form of seminoma. | journal = Virchows Arch A Pathol Anat Histol | volume = 383 | issue = 1 | pages = 59-67 | month = Jul | year = 1979 | doi = | PMID = 157614 }}</ref> | ||
*Granulomatous orchitis - if [[granuloma]]s are present. | *[[Granulomatous orchitis]] - if [[granuloma]]s are present. | ||
*[[Testicular scar]] - seminomas may regress spontaneously. | *[[Testicular scar]] - seminomas may regress spontaneously. | ||