Difference between revisions of "Apocrine carcinoma of the breast"

Jump to navigation Jump to search
Line 66: Line 66:
*ER -ve.  
*ER -ve.  
*PR -ve.
*PR -ve.
*often Her2 -ve
*often Her2 +ve but can be Her2 -ve


Notes
Notes
*Salivary gland carcinoma and cutaneous adnexal tumors can show a similar IHC profile.
*Salivary gland carcinoma and cutaneous adnexal tumors can show a similar IHC profile.
*Apocrine carcioma can be a non-basal type 'triple negative carcinoma' identified by both morphology and AR positivity<ref>{{Cite journal  | last1 = Tsutsumi | first1 = Y. | title = Apocrine carcinoma as triple-negative breast cancer: novel definition of apocrine-type carcinoma as estrogen/progesterone receptor-negative and androgen receptor-positive invasive ductal carcinoma. | journal = Jpn J Clin Oncol | volume = 42 | issue = 5 | pages = 375-86 | month = May | year = 2012 | doi = 10.1093/jjco/hys034 | PMID = 22450930 }}</ref>.
*Apocrine carcioma can be a non-basal type 'triple negative carcinoma' <ref>{{Cite journal  | last1 = Tsutsumi | first1 = Y. | title = Apocrine carcinoma as triple-negative breast cancer: novel definition of apocrine-type carcinoma as estrogen/progesterone receptor-negative and androgen receptor-positive invasive ductal carcinoma. | journal = Jpn J Clin Oncol | volume = 42 | issue = 5 | pages = 375-86 | month = May | year = 2012 | doi = 10.1093/jjco/hys034 | PMID = 22450930 }}</ref>.
**May show different behaviour to other types of triple negative carcinoma
**May show different behaviour to other types of triple negative carcinoma
**May respond to treatments targeting the androgen receptor<ref>{{Cite journal  | last1 = Safarpour | first1 = D. | last2 = Tavassoli | first2 = FA. | title = A Targetable Androgen Receptor-Positive Breast Cancer Subtype Hidden Among the Triple-Negative Cancers. | journal = Arch Pathol Lab Med | volume =  | issue =  | pages =  | month = Oct | year = 2014 | doi = 10.5858/arpa.2014-0122-RA | PMID = 25310144 }}
**May respond to treatments targeting the androgen receptor<ref>{{Cite journal  | last1 = Safarpour | first1 = D. | last2 = Tavassoli | first2 = FA. | title = A Targetable Androgen Receptor-Positive Breast Cancer Subtype Hidden Among the Triple-Negative Cancers. | journal = Arch Pathol Lab Med | volume =  | issue =  | pages =  | month = Oct | year = 2014 | doi = 10.5858/arpa.2014-0122-RA | PMID = 25310144 }}
</ref>
</ref>
**Be carefull when reading the literature in this area - is the author discussing 'molecular apocrine', 'IHC apocrine' or 'morphologic apocrine' carcinoma.  Many ductal carcinomas, NOS will show AR positivity.
*Be careful when reading the literature in this area - is the author discussing 'molecular apocrine' (ER -ve, AR +ve) or 'morphologic apocrine' carcinoma.   
*Many ductal carcinomas, NOS will show AR positivity but are often ER +ve.


==See also==
==See also==
653

edits

Navigation menu