Difference between revisions of "Sertoli-Leydig cell tumour"

Jump to navigation Jump to search
Line 21: Line 21:
# +/- Sarcomatous features (mucinous glands, bone, cartilage).
# +/- Sarcomatous features (mucinous glands, bone, cartilage).


*Well differentiated -
Growth Patterns:
**Mature Sertoli cells form tubules
**Well-differentiated
**Stroma is fibrous and contains clusters of Leydig cells
***Hollow or solid tubules of mature Sertoli cells with Leydig cells in the intervening stroma
*Intermediate to poorly differentiated - 
**Intermediate (most common)
**A more disorganized, more cellular, 'bluer' tumor
***Jumbled admixture of dark blue Sertoli cells and Leydig cells
**Less mature Sertoli cells growing in trabeculae and nests with some tubule formation, either round or retiform.
***Lobules comprising sheets of Sertoli cells
**Leydig cells, either singly or in clusters, are present in an immature, cellular stroma.
***Some areas of tubules.
**Poorly differentiated
***Masses of malignant spindle cells – sheets of cells can be reminiscent of fibrosarcoma or granulosa cell tumour
***Tubules may be a very minor element
**With heterologous element
***Mucinous intestinal-type epithelium, cartilage, skeletal muscle
***Heterologous elements can also occur with retiform or poorly differentiated tumours
**Retiform
***Tumour resembles rete testis/ovary with blunt papillae and irregular cleft-like spaces


DDx:
DDx:
*[[Endometrioid carcinoma of the ovary]] (sertoliform variant) - should be positive for EMA, negative for inhibin and calretinin.
*[[Endometrioid carcinoma of the ovary]] (sertoliform variant) - should be positive for EMA, negative for inhibin and calretinin.
*Luteinized [[adult granulosa cell tumour]] - super rare, 50% of cell with eosinophilic cytoplasm, other findings of granulosa cell tumour, e.g. Call-Exner bodies. More likely to be keratin negative than a Sertoli-Leydig cell tumor. <ref name=pmid21804396>{{Cite journal  | last1 = Ganesan | first1 = R. | last2 = Hirschowitz | first2 = L. | last3 = Baltrušaitytė | first3 = I. | last4 = McCluggage | first4 = WG. | title = Luteinized adult granulosa cell tumor--a series of 9 cases: revisiting a rare variant of adult granulosa cell tumor. | journal = Int J Gynecol Pathol | volume = 30 | issue = 5 | pages = 452-9 | month = Sep | year = 2011 | doi = 10.1097/PGP.0b013e318214b17f | PMID = 21804396 }}</ref>
*Luteinized [[adult granulosa cell tumour]] - super rare, 50% of cell with eosinophilic cytoplasm, other findings of granulosa cell tumour, e.g. Call-Exner bodies. More likely to be keratin negative than a Sertoli-Leydig cell tumor. <ref name=pmid21804396>{{Cite journal  | last1 = Ganesan | first1 = R. | last2 = Hirschowitz | first2 = L. | last3 = Baltrušaitytė | first3 = I. | last4 = McCluggage | first4 = WG. | title = Luteinized adult granulosa cell tumor--a series of 9 cases: revisiting a rare variant of adult granulosa cell tumor. | journal = Int J Gynecol Pathol | volume = 30 | issue = 5 | pages = 452-9 | month = Sep | year = 2011 | doi = 10.1097/PGP.0b013e318214b17f | PMID = 21804396 }}</ref>
 
*Ovarian carcinosarcoma - especially considering poorly differentiated versions with heterologous areas.
===Images===
===Images===
<gallery>
<gallery>
Retrieved from "https://librepathology.org/wiki/Sertoli-Leydig_cell_tumour"