Difference between revisions of "Pleomorphic xanthoastrocytoma"

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~~#redirect~~ [[Neuropathology tumours~~#Pleomorphic xanthoastrocytoma~~]]

'''Pleomorphic xanthoastrocytoma''', abbreviated '''PXA''', is [[neuropathology tumour]] classically associated with seizures.

==General==

Features:

*Classically in the temporal lobe in children and young adults.

*Associated with seizures.

*Moderately aggressive (WHO Grade II).<ref name=pmid11465399>{{Cite journal | last1 = Fouladi | first1 = M. | last2 = Jenkins | first2 = J. | last3 = Burger | first3 = P. | last4 = Langston | first4 = J. | last5 = Merchant | first5 = T. | last6 = Heideman | first6 = R. | last7 = Thompson | first7 = S. | last8 = Sanford | first8 = A. | last9 = Kun | first9 = L. | title = Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection. | journal = Neuro Oncol | volume = 3 | issue = 3 | pages = 184-92 | month = Jul | year = 2001 | doi = | PMID = 11465399 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920613/pdf/11465399.pdf}}</ref>

==Gross==

*Temporal lobe - classic.

*Usually assoc. with the leptomeninges,<ref name=pmid11465399/> i.e. superficial.

==Microscopic==

Features:<ref name=Ref_PBoD8_1333>{{Ref PBoD8|1333}}</ref>

*Marked nuclear atypia.

*Eosinophilic granular bodies - very common.<ref name=pmid11465399/>

*Inflammation (chronic).

Notes:

*No mitoses.

*No [[necrosis]].

===Images===

*[http://path.upmc.edu/cases/case499.html Pleomorphic xanthoastrocytoma - several images (upmc.edu)].

*[http://path.upmc.edu/cases/case511.html Pleomorphic xanthoastrocytoma with anaplasia - another case - several images (upmc.edu)].

*[http://path.upmc.edu/cases/case578.html Pleomorphic xanthoastrocytoma with anaplasia - case 3 - several images (upmc.edu)].

*[http://path.upmc.edu/cases/case579.html Cerebellar pleomorphic xanthoastrocytoma - case 4 - several image (upmc.edu)].

==Stains==

*[[Reticulin stain]] - intercellular, prominent.<ref name=pmid21479234>{{Cite journal | last1 = Dias-Santagata | first1 = D. | last2 = Lam | first2 = Q. | last3 = Vernovsky | first3 = K. | last4 = Vena | first4 = N. | last5 = Lennerz | first5 = JK. | last6 = Borger | first6 = DR. | last7 = Batchelor | first7 = TT. | last8 = Ligon | first8 = KL. | last9 = Iafrate | first9 = AJ. | title = BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications. | journal = PLoS One | volume = 6 | issue = 3 | pages = e17948 | month = | year = 2011 | doi = 10.1371/journal.pone.0017948 | PMID = 21479234 }}</ref>

Image:

*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066220/figure/pone-0017948-g001/ PXA - several images (nih.gov)].<ref name=pmid21479234/>

==IHC==

*GFAP +ve.

*CD68 +ve.

==See also==

*[[Neuropathology tumours]].

==References==

[[Category:Diagnosis]]

[[Category:Neuropathology tumours]]

Difference between revisions of "Pleomorphic xanthoastrocytoma"

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@@ Line 1: / Line 1: @@
-#redirect [[Neuropathology tumours#Pleomorphic xanthoastrocytoma]]
+'''Pleomorphic xanthoastrocytoma''', abbreviated '''PXA''', is [[neuropathology tumour]] classically associated with seizures.
+==General==
+Features:
+*Classically in the temporal lobe in children and young adults.
+*Associated with seizures.
+*Moderately aggressive (WHO Grade II).<ref name=pmid11465399>{{Cite journal  | last1 = Fouladi | first1 = M. | last2 = Jenkins | first2 = J. | last3 = Burger | first3 = P. | last4 = Langston | first4 = J. | last5 = Merchant | first5 = T. | last6 = Heideman | first6 = R. | last7 = Thompson | first7 = S. | last8 = Sanford | first8 = A. | last9 = Kun | first9 = L. | title = Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection. | journal = Neuro Oncol | volume = 3 | issue = 3 | pages = 184-92 | month = Jul | year = 2001 | doi =  | PMID = 11465399 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920613/pdf/11465399.pdf}}</ref>
+==Gross==
+*Temporal lobe - classic.
+*Usually assoc. with the leptomeninges,<ref name=pmid11465399/> i.e. superficial.
+==Microscopic==
+Features:<ref name=Ref_PBoD8_1333>{{Ref PBoD8|1333}}</ref>
+*Marked nuclear atypia.
+*Eosinophilic granular bodies - very common.<ref name=pmid11465399/>
+*Inflammation (chronic).
+Notes:
+*No mitoses.
+*No [[necrosis]].
+===Images===
+*[http://path.upmc.edu/cases/case499.html Pleomorphic xanthoastrocytoma - several images (upmc.edu)].
+*[http://path.upmc.edu/cases/case511.html Pleomorphic xanthoastrocytoma with anaplasia - another case - several images (upmc.edu)].
+*[http://path.upmc.edu/cases/case578.html Pleomorphic xanthoastrocytoma with anaplasia - case 3 - several images (upmc.edu)].
+*[http://path.upmc.edu/cases/case579.html Cerebellar pleomorphic xanthoastrocytoma - case 4 - several image (upmc.edu)].
+==Stains==
+*[[Reticulin stain]] - intercellular, prominent.<ref name=pmid21479234>{{Cite journal  | last1 = Dias-Santagata | first1 = D. | last2 = Lam | first2 = Q. | last3 = Vernovsky | first3 = K. | last4 = Vena | first4 = N. | last5 = Lennerz | first5 = JK. | last6 = Borger | first6 = DR. | last7 = Batchelor | first7 = TT. | last8 = Ligon | first8 = KL. | last9 = Iafrate | first9 = AJ. | title = BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications. | journal = PLoS One | volume = 6 | issue = 3 | pages = e17948 | month =  | year = 2011 | doi = 10.1371/journal.pone.0017948 | PMID = 21479234 }}</ref>
+Image:
+*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066220/figure/pone-0017948-g001/ PXA - several images (nih.gov)].<ref name=pmid21479234/>
+==IHC==
+*GFAP +ve.
+*CD68 +ve.
+==See also==
+*[[Neuropathology tumours]].
+==References==
+{{Reflist|2}}
 [[Category:Diagnosis]]
+[[Category:Neuropathology tumours]]