Difference between revisions of "Craniopharyngioma"

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*Develop from remains of Rathke's pouch or squamous epithelial cell rests.<ref name=pmid17425791>{{Cite journal | last1 = Garnett | first1 = MR. | last2 = Puget | first2 = S. | last3 = Grill | first3 = J. | last4 = Sainte-Rose | first4 = C. | title = Craniopharyngioma. | journal = Orphanet J Rare Dis | volume = 2 | issue = | pages = 18 | month = | year = 2007 | doi = 10.1186/1750-1172-2-18 | PMID = 17425791 }}</ref>

~~Comes in two flavours~~:<ref name=pmid17425791/>

Subtypes:<ref name=pmid17425791/>

*Adamantinomatous type.

**Adults and children.

*Squamous papillary type.

**Adults individuals.<ref name=pmid6696166>{{Cite journal | last1 = Giangaspero | first1 = F. | last2 = Burger | first2 = PC. | last3 = Osborne | first3 = DR. | last4 = Stein | first4 = RB. | title = Suprasellar papillary squamous epithelioma ("papillary craniopharyngioma"). | journal = Am J Surg Pathol | volume = 8 | issue = 1 | pages = 57-64 | month = Jan | year = 1984 | doi = | PMID = 6696166 }}</ref>

**Usually solid.

===Adamantinomatous===

*Adults and children.

*Typically contain mutations in CTNNB1 (the gene that encoding β-catenin).<ref name=pmid25355426>{{Cite journal | last1 = Preda | first1 = V. | last2 = Larkin | first2 = SJ. | last3 = Karavitaki | first3 = N. | last4 = Ansorge | first4 = O. | last5 = Grossman | first5 = AB. | title = The Wnt Signalling Cascade and the Adherens Junction Complex in Craniopharyngioma Tumorigenesis. | journal = Endocr Pathol | volume = | issue = | pages = | month = Oct | year = 2014 | doi = 10.1007/s12022-014-9341-8 | PMID = 25355426 }}</ref>

**Usually intranuclear β-catenin [[immunostain|immunohistochemical]] positivity.

===Papillary===

*Adults individuals.<ref name=pmid6696166>{{Cite journal | last1 = Giangaspero | first1 = F. | last2 = Burger | first2 = PC. | last3 = Osborne | first3 = DR. | last4 = Stein | first4 = RB. | title = Suprasellar papillary squamous epithelioma ("papillary craniopharyngioma"). | journal = Am J Surg Pathol | volume = 8 | issue = 1 | pages = 57-64 | month = Jan | year = 1984 | doi = | PMID = 6696166 }}</ref>

*Usually solid.

==Gross==

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*"Wet" keratin - nests of whorled keratin.

*Calcifications (non-psammomatous).

Often contain mutations in CTNNB1, encoding β-catenin<ref name=pmid25355426>{{Cite journal | last1 = Preda | first1 = V. | last2 = Larkin | first2 = SJ. | last3 = Karavitaki | first3 = N. | last4 = Ansorge | first4 = O. | last5 = Grossman | first5 = AB. | title = The Wnt Signalling Cascade and the Adherens Junction Complex in Craniopharyngioma Tumorigenesis. | journal = Endocr Pathol | volume = | issue = | pages = | month = Oct | year = 2014 | doi = 10.1007/s12022-014-9341-8 | PMID = 25355426 }}</ref> resulting in intranuclear β-catenin immunohistochemical positivity.

====Images====

Difference between revisions of "Craniopharyngioma"

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@@ Line 6: / Line 6: @@
 *Develop from remains of Rathke's pouch or squamous epithelial cell rests.<ref name=pmid17425791>{{Cite journal  | last1 = Garnett | first1 = MR. | last2 = Puget | first2 = S. | last3 = Grill | first3 = J. | last4 = Sainte-Rose | first4 = C. | title = Craniopharyngioma. | journal = Orphanet J Rare Dis | volume = 2 | issue =  | pages = 18 | month =  | year = 2007 | doi = 10.1186/1750-1172-2-18 | PMID = 17425791 }}</ref>
-Comes in two flavours:<ref name=pmid17425791/>
+Subtypes:<ref name=pmid17425791/>
 *Adamantinomatous type.
-**Adults and children.
 *Squamous papillary type.
-**Adults individuals.<ref name=pmid6696166>{{Cite journal  | last1 = Giangaspero | first1 = F. | last2 = Burger | first2 = PC. | last3 = Osborne | first3 = DR. | last4 = Stein | first4 = RB. | title = Suprasellar papillary squamous epithelioma ("papillary craniopharyngioma"). | journal = Am J Surg Pathol | volume = 8 | issue = 1 | pages = 57-64 | month = Jan | year = 1984 | doi =  | PMID = 6696166 }}</ref>
-**Usually solid.
+===Adamantinomatous===
+*Adults and children.
+*Typically contain mutations in CTNNB1 (the gene that encoding β-catenin).<ref name=pmid25355426>{{Cite journal  | last1 = Preda | first1 = V. | last2 = Larkin | first2 = SJ. | last3 = Karavitaki | first3 = N. | last4 = Ansorge | first4 = O. | last5 = Grossman | first5 = AB. | title = The Wnt Signalling Cascade and the Adherens Junction Complex in Craniopharyngioma Tumorigenesis. | journal = Endocr Pathol | volume =  | issue =  | pages =  | month = Oct | year = 2014 | doi = 10.1007/s12022-014-9341-8 | PMID = 25355426 }}</ref>
+**Usually intranuclear β-catenin [[immunostain|immunohistochemical]] positivity.
+===Papillary===
+*Adults individuals.<ref name=pmid6696166>{{Cite journal  | last1 = Giangaspero | first1 = F. | last2 = Burger | first2 = PC. | last3 = Osborne | first3 = DR. | last4 = Stein | first4 = RB. | title = Suprasellar papillary squamous epithelioma ("papillary craniopharyngioma"). | journal = Am J Surg Pathol | volume = 8 | issue = 1 | pages = 57-64 | month = Jan | year = 1984 | doi =  | PMID = 6696166 }}</ref>
+*Usually solid.
 ==Gross==
@@ Line 30: / Line 36: @@
 *"Wet" keratin - nests of whorled keratin.
 *Calcifications (non-psammomatous).
-Often contain mutations in CTNNB1,  encoding β-catenin<ref name=pmid25355426>{{Cite journal  | last1 = Preda | first1 = V. | last2 = Larkin | first2 = SJ. | last3 = Karavitaki | first3 = N. | last4 = Ansorge | first4 = O. | last5 = Grossman | first5 = AB. | title = The Wnt Signalling Cascade and the Adherens Junction Complex in Craniopharyngioma Tumorigenesis. | journal = Endocr Pathol | volume =  | issue =  | pages =  | month = Oct | year = 2014 | doi = 10.1007/s12022-014-9341-8 | PMID = 25355426 }}</ref> resulting in intranuclear β-catenin immunohistochemical positivity.
 ====Images====
 <gallery>