Difference between revisions of "Diffuse large B-cell lymphoma"

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Notes:
Notes:
*Large bizarre cells can occasionally mimic Reed-Sternberg cells, seen in [[Hodgkin lymphoma]].
*Large bizarre cells can occasionally mimic Reed-Sternberg cells, seen in [[Hodgkin lymphoma]].
===Differential diagnosis===
*[[Carcinoma]] - esp. [[small cell carcinoma]].
*[[Anaplastic large cell lymphoma]] (ALCL).
*[[Follicular lymphoma]].
**If a nodular architecture is present it is follicular lymphoma.
*[[Post-transplant lymphoproliferative disorder]] (PTLD) - in organ transplant recipients.
*Primary effusion lymphoma - seen in [[HIV]] infections.
*Mixed cellularity [[Hodgkin lymphoma]] - esp. for T-cell/histiocyte-rich large B cell lymphoma.
*B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma.<ref name=pmid22222636>{{Cite journal  | last1 = Gualco | first1 = G. | last2 = Natkunam | first2 = Y. | last3 = Bacchi | first3 = CE. | title = The spectrum of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: a description of 10 cases. | journal = Mod Pathol | volume =  | issue =  | pages =  | month = Jan | year = 2012 | doi = 10.1038/modpathol.2011.200 | PMID = 22222636 | URL = http://www.nature.com/modpathol/journal/vaop/ncurrent/full/modpathol2011200a.html }}</ref>
*Other [[small round cell tumours]].


===Images===
===Images===
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*Primary effusion lymphoma - associated with [[human immunodeficiency virus]].
*Primary effusion lymphoma - associated with [[human immunodeficiency virus]].
*Lymphomatoid granulomatosis.
*Lymphomatoid granulomatosis.
===Differential diagnosis===
*Carcinoma.
*[[Anaplastic large cell lymphoma]] (ALCL).
*[[Follicular lymphoma]].
**If a nodular architecture is present it is follicular lymphoma.
*[[Post-transplant lymphoproliferative disorder]] (PTLD) - in organ transplant recipients.
*Primary effusion lymphoma - seen in [[HIV]] infections.
*Mixed cellularity [[Hodgkin lymphoma]] - esp. for T-cell/histiocyte-rich large B cell lymphoma.
*B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma.<ref name=pmid22222636>{{Cite journal  | last1 = Gualco | first1 = G. | last2 = Natkunam | first2 = Y. | last3 = Bacchi | first3 = CE. | title = The spectrum of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: a description of 10 cases. | journal = Mod Pathol | volume =  | issue =  | pages =  | month = Jan | year = 2012 | doi = 10.1038/modpathol.2011.200 | PMID = 22222636 | URL = http://www.nature.com/modpathol/journal/vaop/ncurrent/full/modpathol2011200a.html }}</ref>


==IHC==
==IHC==
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