Difference between revisions of "Simple endometrial hyperplasia"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Simple_endometrial_hyperplasia_-_low_mag.jpg | |||
| Width = | |||
| Caption = Simple endometrial hyperplasia. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = irregular dilated glands (described as "animal shapes"), variation of gland size, normal gland density (gland area in plane of section/total area ~= 1/3), +/-nuclear atypia (see below) | |||
| Subtypes = with atypia, without atypia | |||
| LMDDx = [[disordered proliferative endometrium]], [[complex endometrial hyperplasia]], [[Atrophic endometrium|cystic atrophy of the endometrium]], [[benign endometrial polyp]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[endometrium]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = [[abnormal uterine bleeding]] | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = good, may progress to [[endometrial carcinoma]] - esp. with atypia | |||
| Other = | |||
| ClinDDx = other cause of [[abnormal uterine bleeding]] | |||
| Tx = | |||
}} | |||
'''Simple endometrial hyperplasia''', abbreviated '''SEH''', is an uncommon pre-malignant change of the [[endometrium]]. Like [[complex endometrial hyperplasia]], it is subdivided into ''with atypia'' and ''without atypia''. | '''Simple endometrial hyperplasia''', abbreviated '''SEH''', is an uncommon pre-malignant change of the [[endometrium]]. Like [[complex endometrial hyperplasia]], it is subdivided into ''with atypia'' and ''without atypia''. | ||
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**Glands described as "animal shapes". | **Glands described as "animal shapes". | ||
*Variation of gland size. | *Variation of gland size. | ||
*Normal gland density (gland area in plane of section/total area ~= 1/3). | *Normal gland density (gland area in plane of section/total area ~= 1/3). | ||
*+/-Nuclear atypia:<ref>{{Cite journal | last1 = Silverberg | first1 = SG. | title = Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. | journal = Mod Pathol | volume = 13 | issue = 3 | pages = 309-27 | month = Mar | year = 2000 | doi = 10.1038/modpathol.3880053 | PMID = 10757341 }}</ref> | *+/-Nuclear atypia:<ref>{{Cite journal | last1 = Silverberg | first1 = SG. | title = Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. | journal = Mod Pathol | volume = 13 | issue = 3 | pages = 309-27 | month = Mar | year = 2000 | doi = 10.1038/modpathol.3880053 | PMID = 10757341 }}</ref> | ||