Difference between revisions of "Neuromuscular pathology"
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m (→Pathologic) |
m (→IHC) |
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===IHC=== | ===IHC=== | ||
*Dystrophy panel. | *Dystrophy panel. | ||
**Dystrophin<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/310200 http://www.ncbi.nlm.nih.gov/omim/310200]. Accessed on: 29 October 2010.</ref> - Duchenne muscular dystrophy (onset <3 years), Becker's muscular dystrophy (onset 20s or 30s). | **Dystrophin<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/310200 http://www.ncbi.nlm.nih.gov/omim/310200]. Accessed on: 29 October 2010.</ref> - Duchenne muscular dystrophy (onset usu. <3 years), Becker's muscular dystrophy (onset usu. 20s or 30s). | ||
***Membranous staining is normal. Loss of membranous staining = pathologic. | |||
****Tested with three antibodies -- as the protein is hueuge. | |||
**Spectrin - a cause of long QT syndrome. (???) | **Spectrin - a cause of long QT syndrome. (???) | ||
*Lymphocytic markers (CD45, CD3, CD4, CD8, CD20). | *Lymphocytic markers (CD45, CD3, CD4, CD8, CD20). | ||
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*Ubquitin - inclusion body myositis. | *Ubquitin - inclusion body myositis. | ||
*TDP43 - cytoplasmic staining in IBM. | *TDP-43 (also ''TDP43'') - cytoplasmic staining in IBM. | ||
**Normally | **Normally stains the nucleus. | ||
***Same protein that that in implicated in [[ALS]] and [[frontotemporal dementia]]. | |||
==Inflammatory myopathy== | ==Inflammatory myopathy== | ||