48,475
edits
Difference between revisions of "Clear cell carcinoma of the uterine cervix"
Jump to navigation
Jump to search
Clear cell carcinoma of the uterine cervix (view source)
Revision as of 13:42, 24 April 2014
, 13:42, 24 April 2014split out
(redirect) |
(split out) |
||
| Line 1: | Line 1: | ||
'''Clear cell carcinoma of the uterine cervix''' is a rare malignancy of the [[uterine cervix]] that classically is associated with DES exposure. It typically occurs in younger women. | |||
*[[AKA]] ''cervical clear cell carcinoma''. | |||
==General== | |||
*Associated with ''diethylstilbestrol'' exposure ''in utero''.<ref name=pmid19857300>{{Cite journal | last1 = van Dijck | first1 = JA. | last2 = Doorduijn | first2 = Y. | last3 = Bulten | first3 = JH. | last4 = Verloop | first4 = J. | last5 = Massuger | first5 = LF. | last6 = Kiemeney | first6 = BA. | title = [Vaginal and cervical cancer due to diethylstilbestrol (DES); end epidemic] | journal = Ned Tijdschr Geneeskd | volume = 153 | issue = | pages = A366 | month = | year = 2009 | doi = | PMID = 19857300 }}</ref> | |||
*Less common in the cervix - when compared to other gynecologic sites.<ref name=Ref_WMSP442>{{Ref WMSP|442}}</ref> | |||
**More common in the [[clear cell carcinoma of the endometrium|endometrium]].<ref>{{Cite journal | last1 = Babić | first1 = D. | last2 = Kos | first2 = M. | last3 = Jukić | first3 = S. | last4 = Ilić | first4 = J. | last5 = Vecek | first5 = N. | last6 = Kos | first6 = M. | last7 = Mahnik | first7 = N. | title = [Clear cell carcinoma of the female genital tract]. | journal = Jugosl Ginekol Perinatol | volume = 31 | issue = 3-4 | pages = 102-4 | month = | year = | doi = | PMID = 1749271 }}</ref> | |||
*Typical young women - median age ~38 in one series.<ref name=pmid24470762>{{Cite journal | last1 = Jiang | first1 = X. | last2 = Jin | first2 = Y. | last3 = Li | first3 = Y. | last4 = Huang | first4 = HF. | last5 = Wu | first5 = M. | last6 = Shen | first6 = K. | last7 = Pan | first7 = LY. | title = Clear cell carcinoma of the uterine cervix: clinical characteristics and feasibility of fertility-preserving treatment. | journal = Onco Targets Ther | volume = 7 | issue = | pages = 111-6 | month = | year = 2014 | doi = 10.2147/OTT.S53204 | PMID = 24470762 }}</ref> | |||
Note: | |||
*[[HPV]] does '''not''' appear to be important in the oncogenesis;<ref name=pmid21620450>{{Cite journal | last1 = Kocken | first1 = M. | last2 = Baalbergen | first2 = A. | last3 = Snijders | first3 = PJ. | last4 = Bulten | first4 = J. | last5 = Quint | first5 = WG. | last6 = Smedts | first6 = F. | last7 = Meijer | first7 = CJ. | last8 = Helmerhorst | first8 = TJ. | title = High-risk human papillomavirus seems not involved in DES-related and of limited importance in nonDES related clear-cell carcinoma of the cervix. | journal = Gynecol Oncol | volume = 122 | issue = 2 | pages = 297-302 | month = Aug | year = 2011 | doi = 10.1016/j.ygyno.2011.05.002 | PMID = 21620450 }}</ref> however, this is not completely settled.<ref name=pmid22885379/> | |||
==Microscopic== | |||
Features:<ref name=pmid22885379/> | |||
*Like [[clear cell carcinoma]] elsewhere: | |||
**Clear cytoplasm - '''key feature'''. | |||
***May be absent! | |||
**Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface. | |||
**Moderate-to-severe [[nuclear pleomorphism]]. | |||
**Tubular and/or cystic morphology. | |||
***May be (simple) papillary and/or solid. | |||
*Adenosis - typically adjacent. | |||
DDx: | |||
*[[Clear cell carcinoma of the endometrium]] - diagnosis based on clinico-radiologic correlation (IHC & histology not useful).<ref name=pmid22885379>{{Cite journal | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref> | |||
*[[Serous carcinoma of the endometrium]]. | |||
*[[Serous carcinoma of the uterine cervix]]. | |||
==IHC== | |||
*Essentially considered to be like ''[[endometrial clear cell carcinoma]]''.<ref name=pmid22885379/> | |||
==See also== | |||
*[[Uterine cervix]]. | |||
*[[Clear cell carcinoma]]. | |||
*[[Clear cell carcinoma of the vagina]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Uterine cervix]] | |||