Difference between revisions of "Differentiated vulvar intraepithelial neoplasia"
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*[http://www.nature.com/modpathol/journal/v23/n3/fig_tab/modpathol2009179f1.html Differentiated VIN with bridging rete ridges (nature.com)].<ref name=pmid20062014>{{Cite journal | last1 = Pinto | first1 = AP. | last2 = Miron | first2 = A. | last3 = Yassin | first3 = Y. | last4 = Monte | first4 = N. | last5 = Woo | first5 = TY. | last6 = Mehra | first6 = KK. | last7 = Medeiros | first7 = F. | last8 = Crum | first8 = CP. | title = Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma. | journal = Mod Pathol | volume = 23 | issue = 3 | pages = 404-12 | month = Mar | year = 2010 | doi = 10.1038/modpathol.2009.179 | PMID = 20062014 }}</ref> | *[http://www.nature.com/modpathol/journal/v23/n3/fig_tab/modpathol2009179f1.html Differentiated VIN with bridging rete ridges (nature.com)].<ref name=pmid20062014>{{Cite journal | last1 = Pinto | first1 = AP. | last2 = Miron | first2 = A. | last3 = Yassin | first3 = Y. | last4 = Monte | first4 = N. | last5 = Woo | first5 = TY. | last6 = Mehra | first6 = KK. | last7 = Medeiros | first7 = F. | last8 = Crum | first8 = CP. | title = Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma. | journal = Mod Pathol | volume = 23 | issue = 3 | pages = 404-12 | month = Mar | year = 2010 | doi = 10.1038/modpathol.2009.179 | PMID = 20062014 }}</ref> | ||
==IHC== | |||
*Differentiated VIN: p16 -ve, p53 +ve.<ref name=pmid20062014/> | *Differentiated VIN: p16 -ve, p53 +ve.<ref name=pmid20062014/> | ||
*Classic VIN: p16 +ve, p53 -ve. | *Classic VIN: p16 +ve, p53 -ve. | ||
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Note: | Note: | ||
*p16 can be thought of as a poor man's [[HPV]] test. | *p16 can be thought of as a poor man's [[HPV]] test. | ||
==Sign out== | |||
<pre> | |||
LABIA MINUS, RIGHT, PUNCH BIOPSY: | |||
- DIFFERENTIATED VULVAR INTRAEPITHELIAL NEOPLASIA. | |||
- LICHEN SCLEROSUS. | |||
</pre> | |||
==See also== | ==See also== | ||