Difference between revisions of "Neurodegenerative diseases"
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(→Multiple system atrophy: subdivide) |
(→Lewy body diseases: create alzheimer) |
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*Hippocampus (essential for forming new memories). | *Hippocampus (essential for forming new memories). | ||
*Frontal lobe (essential for retrieval of memories). | *Frontal lobe (essential for retrieval of memories). | ||
==Alzheimer disease== | |||
===General=== | |||
*Onset: episodic memory loss. | |||
===Gross=== | |||
Features: | |||
*Temporal atrophy, esp. hippocampus. | |||
*Dilation of: | |||
**Lateral ventricles. | |||
**Third ventricle. | |||
===Microscopic=== | |||
Features: | |||
#Neurofibrillary tangles. | |||
#*Consists of ''tau''. | |||
#*Location: hippocampus, cerebral cortex., hypothalamus. | |||
#Senile plaques. | |||
#*Consists of two components: | |||
#*#Centre - radiates. | |||
#*#*Consists of Abeta amyloid | |||
#*#Neurites - swollen axons. | |||
Notes: | |||
*Abeta amyloid: | |||
**Derived from ''amyloid precursor protein'' (APP). | |||
***APP: | |||
****Rapid axonal transport - useful as a marker of axonal injury. | |||
****Function currently not known. | |||
*Tau: | |||
**Important in microtubule assembly. | |||
==Lewy body diseases== | ==Lewy body diseases== | ||