Difference between revisions of "Neurodegenerative diseases"
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==Overview== | ==Overview== | ||
* | *Neurodegenerative disease = essentially progressive and selective neuron loss. | ||
*Clinically, they are not unique, e.g. dementia can be caused by several diseases (with different molecular etiologies). | *Clinically, they are not unique, e.g. dementia can be caused by several diseases (with different molecular etiologies). | ||
**Each syndrome (e.g. dementia, parkinsonism, ataxia) has a most common etiology and a DDx. | |||
*They are defined by molecular pathology.<ref name=pmid19918325>{{cite journal |author=Dickson DW |title=Neuropathology of non-Alzheimer degenerative disorders |journal=Int J Clin Exp Pathol |volume=3 |issue=1 |pages=1–23 |year=2009 |pmid=19918325 |pmc=2776269 |doi= |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776269/?tool=pubmed}}</ref> | *They are defined by molecular pathology.<ref name=pmid19918325>{{cite journal |author=Dickson DW |title=Neuropathology of non-Alzheimer degenerative disorders |journal=Int J Clin Exp Pathol |volume=3 |issue=1 |pages=1–23 |year=2009 |pmid=19918325 |pmc=2776269 |doi= |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776269/?tool=pubmed}}</ref> | ||
**The diseases are due to the accumulation of abnormal protein. | **The diseases are due to the accumulation of abnormal protein. | ||
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| brainstem | | brainstem | ||
| parkinsonism | | parkinsonism | ||
| | | Lewy bodies | ||
| Image? | | Image? | ||
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| corticolimbic, brainstem | | corticolimbic, brainstem | ||
| dementia + parkinsonism | | dementia + parkinsonism | ||
| | | Lewy bodies | ||
| Image? | | Image? | ||
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