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Difference between revisions of "Neurodegenerative diseases"
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Neurodegenerative diseases (view source)
Revision as of 19:52, 20 November 2010
, 19:52, 20 November 2010→IHC: more, subdivide section
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==IHC== | ==IHC== | ||
===Tau=== | |||
*AT-8 = stains phosphorylated tau.<ref name=pmid19946779>{{cite journal |author=Seelaar H, Klijnsma KY, de Koning I, ''et al.'' |title=Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration |journal=J. Neurol. |volume=257 |issue=5 |pages=747–53 |year=2010 |month=May |pmid=19946779 |pmc=2864899 |doi=10.1007/s00415-009-5404-z |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864899/}}</ref> | *AT-8 = stains phosphorylated tau.<ref name=pmid19946779>{{cite journal |author=Seelaar H, Klijnsma KY, de Koning I, ''et al.'' |title=Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration |journal=J. Neurol. |volume=257 |issue=5 |pages=747–53 |year=2010 |month=May |pmid=19946779 |pmc=2864899 |doi=10.1007/s00415-009-5404-z |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864899/}}</ref> | ||
* | |||
===TDP-43=== | |||
*May accumulate due to a ''progranulin mutation''. | |||
====Microscopic==== | |||
*TDP-43 - normally in the nucleus. | *TDP-43 - normally in the nucleus. | ||
**Pathologic: [http://archneur.ama-assn.org/cgi/content/full/65/5/636/NOC70108F2 Micrograph (label B) - neurites, skein-like formations (ama-assn.org)]<ref>{{cite journal |author=Geser F, Brandmeir NJ, Kwong LK, ''et al.'' |title=Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis |journal=Arch. Neurol. |volume=65 |issue=5 |pages=636–41 |year=2008 |month=May |pmid=18474740 |doi=10.1001/archneur.65.5.636 |url=}}</ref> | **Pathologic: [http://archneur.ama-assn.org/cgi/content/full/65/5/636/NOC70108F2 Micrograph (label B) - neurites, skein-like formations (ama-assn.org)]<ref>{{cite journal |author=Geser F, Brandmeir NJ, Kwong LK, ''et al.'' |title=Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis |journal=Arch. Neurol. |volume=65 |issue=5 |pages=636–41 |year=2008 |month=May |pmid=18474740 |doi=10.1001/archneur.65.5.636 |url=}}</ref> | ||
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****"Skein" = ''yarn or thread wound on a reel'' or ''flock of birds in flight''.<ref>URL: [http://dictionary.reference.com/browse/skein http://dictionary.reference.com/browse/skein]. Accessed on: 20 November 2010.</ref> | ****"Skein" = ''yarn or thread wound on a reel'' or ''flock of birds in flight''.<ref>URL: [http://dictionary.reference.com/browse/skein http://dictionary.reference.com/browse/skein]. Accessed on: 20 November 2010.</ref> | ||
***''Neurites'' = "squiggly appearance"; "worm-like appearance". | ***''Neurites'' = "squiggly appearance"; "worm-like appearance". | ||
===Ubiquitin=== | |||
*Marks proteins for recycling. | |||
====Microscopic==== | |||
*p62; poli-ubiquitin-binding protein p62.<ref name=pmid19946779/> | |||
==Clinical perspective (becoming obsolete)== | ==Clinical perspective (becoming obsolete)== | ||