Difference between revisions of "Meningioma"
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==IHC== | ==IHC== | ||
*EMA +ve.<ref name=Ref_PSNP13>{{Ref PSNP|13}}</ref> | *EMA +ve.<ref name=Ref_PSNP13>{{Ref PSNP|13}}</ref> | ||
*Other CKs usually -ve. | |||
DDx of meningioma & IHC:<ref name=pmid16393681>{{cite journal |author=Hahn HP, Bundock EA, Hornick JL |title=Immunohistochemical staining for claudin-1 can help distinguish meningiomas from histologic mimics |journal=Am. J. Clin. Pathol. |volume=125 |issue=2 |pages=203–8 |year=2006 |month=February |pmid=16393681 |doi=10.1309/G659-FVVB-MG7U-4RPQ |url=http://ajcp.ascpjournals.org/content/125/2/203.full.pdf}}</ref> | |||
*S-100 +ve - schwannoma. | |||
**+ve in ~80% of fibrous meningiomas. | |||
*CD34 +ve - solitary fibrous tumour. | |||
**+ve in ~60% of fibrous meningiomas. | |||
*EMA +ve in ~30% of hemangiopericytoma.<ref name=pmid16393681>{{cite journal |author=Hahn HP, Bundock EA, Hornick JL |title=Immunohistochemical staining for claudin-1 can help distinguish meningiomas from histologic mimics |journal=Am. J. Clin. Pathol. |volume=125 |issue=2 |pages=203–8 |year=2006 |month=February |pmid=16393681 |doi=10.1309/G659-FVVB-MG7U-4RPQ |url=http://ajcp.ascpjournals.org/content/125/2/203.full.pdf}}</ref> | |||
*Claudin-1 - new kid on the block: +ve in meningioma, but low sensitivity. | |||
===Standard work-up (UHN)<ref>Croul, SE. 8 November 2010.</ref>=== | ===Standard work-up (UHN)<ref>Croul, SE. 8 November 2010.</ref>=== | ||