Difference between revisions of "Amyloid"
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| Caption = Cardiac amyloidosis. [[H&E stain]]. | | Caption = Cardiac amyloidosis. [[H&E stain]]. | ||
| Micro = typically extracellular, amorphous (no specific shape), acellular and pink (on [[H&E stain]]) -- cotton candy like, classically has a "cracked" appearance | | Micro = typically extracellular, amorphous (no specific shape), acellular and pink (on [[H&E stain]]) -- cotton candy like, classically has a "cracked" appearance | ||
| Subtypes = | | Subtypes = multiple subclassifications: ''Robbins'' (AL amyloidosis, AA amyloidosis, non-AA and non-AL), ''set of six subtypes'' (primary (AL amyloidosis), secondary (AA amyloidosis, hemodialysis-related, localized), hereditary, senile systemic amyloidosis) | ||
| LMDDx = fibrin, collagen, smooth muscle | | LMDDx = fibrin, collagen, smooth muscle | ||
| Stains = [[Congo red]] +ve | | Stains = [[Congo red]] +ve | ||
| IHC = | | IHC = | ||
| EM = | | EM = non-branching fine fibrils - usually 8-12 nm in diameter (accepted range 8-15 nm) | ||
| Molecular = | | Molecular = beta sheet | ||
| IF = | | IF = | ||
| Gross = waxy appearance | | Gross = waxy appearance | ||
| Grossing = | | Grossing = | ||
| Site = pretty much anywhere | | Site = pretty much anywhere | ||
| Assdx = | | Assdx = very many | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = variable | | Clinicalhx = variable | ||