Difference between revisions of "Endometrial stromal sarcoma"
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(→Microscopic: tweak some more) |
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| Micro = highly cellular islands of (tumour) cells with a wavy irregular border -- benign uterine smooth muscle between; tumour cells: high [[NC ratio]] and epithelioid, pallisade around thin blood vessels within the tumour | | Micro = highly cellular islands of (tumour) cells with a wavy irregular border -- benign uterine smooth muscle between; tumour cells: high [[NC ratio]] and epithelioid, pallisade around thin blood vessels within the tumour | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[leiomyoma]] (cellular), [[endometrial stromal nodule]], [[ | | LMDDx = [[leiomyoma]] (cellular), [[endometrial stromal nodule]], [[uterine leiomyosarcoma]] | ||
| Stains = | | Stains = | ||
| IHC = CD10 +ve, H-caldesmin -ve, PR +/-ve, ER +/-ve | | IHC = CD10 +ve, H-caldesmin -ve, PR +/-ve, ER +/-ve | ||
| Line 24: | Line 24: | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = good | ||
| Other = | | Other = | ||
| ClinDDx = other [[uterine tumours]] | | ClinDDx = other [[uterine tumours]] | ||
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==General== | ==General== | ||
*Uncommon.<ref name=pmid20179433> {{Cite journal | last1 = Chew | first1 = I. | last2 = Oliva | first2 = E. | title = Endometrial stromal sarcomas: a review of potential prognostic factors. | journal = Adv Anat Pathol | volume = 17 | issue = 2 | pages = 113-21 | month = Mar | year = 2010 | doi = 10.1097/PAP.0b013e3181cfb7c2 | PMID = 20179433 }}</ref> | *Uncommon.<ref name=pmid20179433> {{Cite journal | last1 = Chew | first1 = I. | last2 = Oliva | first2 = E. | title = Endometrial stromal sarcomas: a review of potential prognostic factors. | journal = Adv Anat Pathol | volume = 17 | issue = 2 | pages = 113-21 | month = Mar | year = 2010 | doi = 10.1097/PAP.0b013e3181cfb7c2 | PMID = 20179433 }}</ref> | ||
*Prognosis good | *Prognosis good<ref name=pmid24146786></ref> > 90% five year survival and > 85% ten year survival<ref name=pmid24184602>{{Cite journal | last1 = Yoon | first1 = A. | last2 = Park | first2 = JY. | last3 = Park | first3 = JY. | last4 = Lee | first4 = YY. | last5 = Kim | first5 = TJ. | last6 = Choi | first6 = CH. | last7 = Bae | first7 = DS. | last8 = Kim | first8 = BG. | last9 = Lee | first9 = JW. | title = Prognostic factors and outcomes in endometrial stromal sarcoma with the 2009 FIGO staging system: A multicenter review of 114 cases. | journal = Gynecol Oncol | volume = | issue = | pages = | month = Oct | year = 2013 | doi = 10.1016/j.ygyno.2013.10.029 | PMID = 24184602 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
| Line 79: | Line 79: | ||
*PR +/-ve. | *PR +/-ve. | ||
*ER +/-ve. | *ER +/-ve. | ||
*CD117 +ve (~80%).<ref>{{Cite journal | last1 = Park | first1 = JY. | last2 = Kim | first2 = KR. | last3 = Nam | first3 = JH. | title = Immunohistochemical analysis for therapeutic targets and prognostic markers in low-grade endometrial stromal sarcoma. | journal = Int J Gynecol Cancer | volume = 23 | issue = 1 | pages = 81-9 | month = Jan | year = 2013 | doi = 10.1097/IGC.0b013e3182738361 | PMID = 23221606 }}</ref> | |||
==Molecular== | ==Molecular== | ||