Difference between revisions of "Esophagus"
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The above findings are suggestive of eosinophilic esophagitis in the proper | The above findings are suggestive of eosinophilic esophagitis in the proper | ||
clinical context. | clinical context. | ||
</pre> | |||
====Patchy eosinophils==== | |||
<pre> | |||
ESOPHAGUS (DISTAL), BIOPSY: | |||
- SQUAMOUS MUCOSA WITH BASAL CELL HYPERPLASIA, INTRAEPITHELIAL EDEMA AND ONLY | |||
FOCALLY ABUNDANT INTRAEPITHELIAL EOSINOPHILS, SEE COMMENT. | |||
- COLUMNAR EPITHELIUM WITH MODERATE CHRONIC INFLAMMATION, AND PANCREATIC | |||
ACINAR METAPLASIA. | |||
- NEGATIVE FOR INTESTINAL METAPLASIA. | |||
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. | |||
COMMENT - PART B: | |||
One high power field (field diamter 0.55 mm) has 25 eosinophils. The findings are | |||
compatible with gastroesophageal reflux; however, eosinophilic esophagitis is also a | |||
consideration. Clinical correlation is required. | |||
Literature valves show a large variation when defining eosinophilic esophagitis | |||
and frequently use "HPF" as a measure of area, which is not a standardized measure. | |||
[Am. J. Gastroenterol. 102 (10): 2300 13.] | |||
Common cut-points are 15 eosinophils/HPF and 20 eosinophils/HPF, where HPF is | |||
often undefined. | |||
</pre> | </pre> | ||