Difference between revisions of "Dermatologic neoplasms"

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==Microcystic adnexal carcinoma==
==Microcystic adnexal carcinoma==
*[[AKA]] ''syringomatous carcinoma'', [[AKA]] ''sclerosing sweat duct carcinoma''.<ref name=dermaamin>URL: [http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html]. Accessed on: 16 September 2011.</ref>
{{Main|Microcystic adnexal carcinoma}}
===General===
*Low-grade tumour.
*Adults.
 
===Microscopic===
Features:<ref>{{Ref Derm|412}}</ref>
*Small basaloid cells - often forming small cystic spaces - '''key feature'''.
**Very bland cytology.
*Fibrotic stroma.
 
DDx:
*[[Sclerosing basal cell carcinoma]].
*Desmoplastic [[trichoepithelioma]] (DTE).<ref name=pmid22366669>{{Cite journal  | last1 = Kirzhner | first1 = M. | last2 = Jakobiec | first2 = FA. | last3 = Borodic | first3 = G. | title = Desmoplastic trichoepithelioma: report of a unique periocular case. | journal = Ophthal Plast Reconstr Surg | volume = 28 | issue = 5 | pages = e121-3 | month =  | year =  | doi = 10.1097/IOP.0b013e318245535a | PMID = 22366669 }}</ref>
*Infiltrative [[squamous cell carcinoma]].
 
Image:
*[http://www.dermaamin.com/site/images/histo-pic/m/microcystic-adnexal-carcinoma/microcystic-adnexal-carcinoma2.jpg Microcystic adnexal carcinoma (dermaamin.com)].<ref name=dermaamin>URL: [http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html]. Accessed on: 16 September 2011.</ref>
 
===IHC===
Features:<ref name=pmid23398472 >{{Cite journal  | last1 = Sellheyer | first1 = K. | last2 = Nelson | first2 = P. | last3 = Kutzner | first3 = H. | last4 = Patel | first4 = RM. | title = The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. | journal = J Cutan Pathol | volume = 40 | issue = 4 | pages = 363-70 | month = Apr | year = 2013 | doi = 10.1111/cup.12085 | PMID = 23398472 }}</ref>
*BerEP4 -ve.
**Positive in [[sclerosing basal cell carcinoma]].
*CK15 -ve.
**Positive in DTE.
**Negative in sclerosing BCC.


==Trichilemmal carcinoma==
==Trichilemmal carcinoma==
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