Difference between revisions of "Neuromuscular pathology"

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Special - mitochondrial pathology.:
*SDH (Succinate dehydrogenase).
*COX.
*COX-SDH.


Enzymatic/genetic stuff:
===ATPase stain pattern/fibre type===
{| class="wikitable"
|
| '''Type 1<br>slow twitch'''
| '''Type 2<br>fast twitch'''
|-
| '''pH 4.2'''
| '''dark'''
| light
|-
| '''pH 9.4'''
| light
| '''dark'''
|}
 
===Special - mitochondrial pathology===
{| class="wikitable"
| '''Stain'''
| '''Comment'''
| '''Image'''
|-
|Succinate <br>dehydrogenase (SDH)
|
| [http://moon.ouhsc.edu/kfung/JTY1/Com04/Com04Image/Com401-3-03.gif]<ref name=ouhsc1>URL: [http://moon.ouhsc.edu/kfung/JTY1/Com04/Com401-3-Diss.htm http://moon.ouhsc.edu/kfung/JTY1/Com04/Com401-3-Diss.htm]. Accessed on: 28 October 2010.</ref>
|-
|COX
|
| [http://moon.ouhsc.edu/kfung/JTY1/Com04/Com04Image/Com401-3-09.gif]<ref name=ouhsc1>URL: [http://moon.ouhsc.edu/kfung/JTY1/Com04/Com401-3-Diss.htm http://moon.ouhsc.edu/kfung/JTY1/Com04/Com401-3-Diss.htm]. Accessed on: 28 October 2010.</ref>
|-
|COX-SDH
|
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|}
 
===Enzymatic/genetic stuff===
*Phosphorylase.
*Phosphorylase.
*Adenylate deaminase.
*Adenylate deaminase.
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**Image: [http://neuromuscular.wustl.edu/pics/biopsy/rods/rodhptb2.jpg Nemaline rods (wustl.edu)].<ref>URL: [http://neuromuscular.wustl.edu/pathol/rod.htm http://neuromuscular.wustl.edu/pathol/rod.htm]. Accessed on: 26 October 2010.</ref>
**Image: [http://neuromuscular.wustl.edu/pics/biopsy/rods/rodhptb2.jpg Nemaline rods (wustl.edu)].<ref>URL: [http://neuromuscular.wustl.edu/pathol/rod.htm http://neuromuscular.wustl.edu/pathol/rod.htm]. Accessed on: 26 October 2010.</ref>


IHC:
===IHC===
*Dystrophy panel.
*Dystrophy panel.
**Dystrophin<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/310200 http://www.ncbi.nlm.nih.gov/omim/310200]. Accessed on: 29 October 2010.</ref> - Duchenne muscular dystrophy (onset <3 years), Becker's muscular dystrophy (onset 20s or 30s).
**Spectrin - a cause of long QT syndrome. (???)
*Lymphocytic markers (CD45, CD3, CD4, CD8, CD20).
*Lymphocytic markers (CD45, CD3, CD4, CD8, CD20).
*MAC - inclusion body myositis.
*MAC - inclusion body myositis.
*APP - inclusion body myositis.  
*APP - inclusion body myositis.  
*Ubquitin - inclusion body myositis.
*Ubquitin - inclusion body myositis.
===ATPase stain pattern/fibre type===
{| class="wikitable"
|
| '''Type 1<br>slow twitch'''
| '''Type 2<br>fast twitch'''
|-
| '''pH 4.2'''
| '''dark'''
| light
|-
| '''pH 9.4'''
| light
| '''dark'''
|}


==Inflammatory myopathy==
==Inflammatory myopathy==
Retrieved from "https://librepathology.org/wiki/Neuromuscular_pathology"