Difference between revisions of "Chondro-osseous tumours"

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*Ctyologically benign cells is spaced nests.
*Ctyologically benign cells is spaced nests.


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Enchondroma_-_intermed_mag.jpg Enchondroma - intermed mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Enchondroma_-_very_high_mag.jpg Enchondroma - very high mag. (WC)].
Image:Enchondroma_-_intermed_mag.jpg | Enchondroma - intermed mag. (WC)
 
Image:Enchondroma_-_very_high_mag.jpg | Enchondroma - very high mag. (WC)
</gallery>
==Chondroblastoma==
==Chondroblastoma==
===General===
===General===
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*Well-differentiated [[chondrosarcoma]].
*Well-differentiated [[chondrosarcoma]].


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Chondroblastoma_-_intermed_mag.jpg Chondroblastoma - intermed. mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Chondroblastoma_-_very_high_mag.jpg Chondroblastoma - very high mag. (WC)].
Image:Chondroblastoma_-_intermed_mag.jpg | Chondroblastoma - intermed. mag. (WC)
Image:Chondroblastoma_-_very_high_mag.jpg | Chondroblastoma - very high mag. (WC)
</gallery>
www:
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-996.jpg Chondroblastoma (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref>
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-996.jpg Chondroblastoma (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref>
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-997.jpg Chondroblastoma with "chickenwire" appearance (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref>
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-997.jpg Chondroblastoma with "chickenwire" appearance (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref>
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*[[Osteosarcoma]] - esp. [[chondroblastic osteosarcoma]] - has osteoid, may be focal.
*[[Osteosarcoma]] - esp. [[chondroblastic osteosarcoma]] - has osteoid, may be focal.


Images:
=====Images=====
*[[WC]]:
<gallery>
**[http://commons.wikimedia.org/wiki/File:Chondrosarcoma_(1).jpg Chondrosarcoma - low mag. (WC)].
Image:Chondrosarcoma_(1).jpg | Chondrosarcoma - low mag. (WC)
**[http://commons.wikimedia.org/wiki/File:Chondrosarcoma_(2).jpg Chondrosarcoma - high mag. (WC)].
Image:Chondrosarcoma_(2).jpg | Chondrosarcoma - high mag. (WC)
**[http://commons.wikimedia.org/wiki/File:Chondrosarcoma_(3).jpg Chondrosarcoma - high mag. (WC)].
Image:Chondrosarcoma_(3).jpg | Chondrosarcoma - high mag. (WC)
</gallery>
*www:
*www:
**[http://path.upmc.edu/cases/case168.html Chondrosarcoma (upmc.edu)].
**[http://path.upmc.edu/cases/case168.html Chondrosarcoma (upmc.edu)].
Line 544: Line 549:
*Histomorphologically near identical/indistinguishable from ''[[osteoblastoma]]''.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref>
*Histomorphologically near identical/indistinguishable from ''[[osteoblastoma]]''.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref>


Images:
====Images====
<gallery>
Image:Osteoid_osteoma_-_low_mag.jpg | Osteoid osteoma - low mag. (WC)
Image:Osteoid_osteoma_-_high_mag.jpg | Osteoid osteoma - high mag. (WC)
</gallery>
www:
*[http://library.med.utah.edu/WebPath/COW/COW211.html Osteoid osteoma - CT scan (med.utah.edu)].
*[http://library.med.utah.edu/WebPath/COW/COW211.html Osteoid osteoma - CT scan (med.utah.edu)].
*[http://www.sciencephoto.com/images/imagePopUpDetails.html?pop=1&id=700030210&pviewid=&country=67&search=gschmeissners&matchtype=FUZZY Osteoid osteoma (sciencephoto.com)].
*[http://www.sciencephoto.com/images/imagePopUpDetails.html?pop=1&id=700030210&pviewid=&country=67&search=gschmeissners&matchtype=FUZZY Osteoid osteoma (sciencephoto.com)].
*[http://commons.wikimedia.org/w/index.php?title=File:Osteoid_osteoma_-_low_mag.jpg Osteoid osteoma - low mag. (WC)].
*[http://commons.wikimedia.org/w/index.php?title=File:Osteoid_osteoma_-_high_mag.jpg Osteoid osteoma - high mag. (WC)].


==Osteoblastoma==
==Osteoblastoma==
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*'''Must''' be greater 1.5 cm by definition.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref>
*'''Must''' be greater 1.5 cm by definition.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref>


Images:
====Images====
*[http://commons.wikimedia.org/w/index.php?title=File:Osteoblastoma_-_high_mag.jpg Osteoblastoma - high mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/w/index.php?title=File:Osteoblastoma_-_low_mag.jpg Osteoblastoma - low mag. (WC)].
Image:Osteoblastoma_-_high_mag.jpg | Osteoblastoma - high mag. (WC)
 
Image:Osteoblastoma_-_low_mag.jpg | Osteoblastoma - low mag. (WC)
</gallery>
==Ewing sarcoma==
==Ewing sarcoma==
*[[AKA]] EWS/pPNET, AKA (confusingly) EWS/PNET:
*[[AKA]] EWS/pPNET, AKA (confusingly) EWS/PNET:
Line 613: Line 622:
*[[Rhabdomyosarcoma]] occasionally has cytoplasmic clearing (due to glycogen).<ref name=PST14feb11>PST. 14 February 2011.</ref>
*[[Rhabdomyosarcoma]] occasionally has cytoplasmic clearing (due to glycogen).<ref name=PST14feb11>PST. 14 February 2011.</ref>


Images:
====Images====
*[[WC]]:
<gallery>
**[http://commons.wikimedia.org/wiki/File:Ewing_sarcoma_-_very_high_mag.jpg ES - very high mag. (WC)].
Image:Ewing_sarcoma_-_very_high_mag.jpg | ES - very high mag. (WC)
**[http://commons.wikimedia.org/wiki/File:Ewing_sarcoma_-_PAS_-_very_high_mag.jpg ES - PAS - very high mag. (WC)].
Image:Ewing_sarcoma_-_PAS_-_very_high_mag.jpg | ES - PAS - very high mag. (WC)
*www:
</gallery>
**[http://path.upmc.edu/cases/case103.html Ewing sarcoma - case 1 - several images (upmc.edu)].
www:
**[http://path.upmc.edu/cases/case420.html Ewing sarcoma - case 2 - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case103.html Ewing sarcoma - case 1 - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case420.html Ewing sarcoma - case 2 - several images (upmc.edu)].


===[[IHC]]===
===[[IHC]]===
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*Large (multinucleated) osteoclast-like giant cells may be seen.<ref>{{cite journal |author=Papalas JA, Balmer NN, Wallace C, Sangueeza OP |title=Ossifying dermatofibroma with osteoclast-like giant cells: report of a case and literature review |journal=Am J Dermatopathol |volume=31 |issue=4 |pages=379-83 |year=2009 |month=June |pmid=19461244 |doi=10.1097/DAD.0b013e3181966747 |url=}}</ref>
*Large (multinucleated) osteoclast-like giant cells may be seen.<ref>{{cite journal |author=Papalas JA, Balmer NN, Wallace C, Sangueeza OP |title=Ossifying dermatofibroma with osteoclast-like giant cells: report of a case and literature review |journal=Am J Dermatopathol |volume=31 |issue=4 |pages=379-83 |year=2009 |month=June |pmid=19461244 |doi=10.1097/DAD.0b013e3181966747 |url=}}</ref>


Images:
=====Images=====
*[http://commons.wikimedia.org/wiki/File:Osteosarcoma_-_intermed_mag.jpg Osteosarcoma - intermed. mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Osteosarcoma_-_very_high_mag.jpg Osteosarcoma - very high mag. (WC)].
Image:Osteosarcoma_-_intermed_mag.jpg | Osteosarcoma - intermed. mag. (WC)
*[http://commons.wikimedia.org/wiki/File:Small_cell_osteosarcoma_-_intermed_mag.jpg Small cell osteosarcoma - intermed. mag. (WC)].
Image:Osteosarcoma_-_very_high_mag.jpg | Osteosarcoma - very high mag. (WC)
*[http://commons.wikimedia.org/wiki/File:Small_cell_osteosarcoma_-_high_mag.jpg Small cell osteosarcoma - high mag. (WC)].
Image:Small_cell_osteosarcoma_-_intermed_mag.jpg | Small cell osteosarcoma - intermed. mag. (WC)
Image:Small_cell_osteosarcoma_-_high_mag.jpg | Small cell osteosarcoma - high mag. (WC)
</gallery>


====Subtypes====
====Subtypes====
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**[[Aneurysmal bone cyst]] - typically has spindle cells around the giant cells.
**[[Aneurysmal bone cyst]] - typically has spindle cells around the giant cells.


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Giant_cell_tumour_of_bone_-_high_mag.jpg GCT of bone - high mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Giant_cell_tumour_of_bone_-_low_mag.jpg GCT of bone - low mag. (WC)].
Image:Giant_cell_tumour_of_bone_-_high_mag.jpg | GCT of bone - high mag. (WC)
 
Image:Giant_cell_tumour_of_bone_-_low_mag.jpg | GCT of bone - low mag. (WC)
</gallery>
===IHC===
===IHC===
*p63 +ve in scattered mononuclear cells.<ref name=pmid18311114>{{cite journal |author=Dickson BC, Li SQ, Wunder JS, ''et al.'' |title=Giant cell tumor of bone express p63 |journal=Mod. Pathol. |volume=21 |issue=4 |pages=369–75 |year=2008 |month=April |pmid=18311114 |doi=10.1038/modpathol.2008.29 |url=}}</ref>
*p63 +ve in scattered mononuclear cells.<ref name=pmid18311114>{{cite journal |author=Dickson BC, Li SQ, Wunder JS, ''et al.'' |title=Giant cell tumor of bone express p63 |journal=Mod. Pathol. |volume=21 |issue=4 |pages=369–75 |year=2008 |month=April |pmid=18311114 |doi=10.1038/modpathol.2008.29 |url=}}</ref>
Line 869: Line 882:
*Foam cells.
*Foam cells.


Images:
====Images====
*[[WC]]:
<gallery>
**[http://commons.wikimedia.org/wiki/File:Pigmented_villonodular_synovitis_low_mag.jpg PVNS - low mag. (WC)].
Image:Pigmented_villonodular_synovitis_low_mag.jpg | PVNS - low mag. (WC)
**[http://commons.wikimedia.org/wiki/File:Pigmented_villonodular_synovitis_high_mag.jpg PVNS - high mag. (WC)].
Image:Pigmented_villonodular_synovitis_high_mag.jpg | PVNS - high mag. (WC)
*www:
</gallery>
**[http://path.upmc.edu/cases/case251/micro.html PVNS - several images (upmc.edu)].
www:
*[http://path.upmc.edu/cases/case251/micro.html PVNS - several images (upmc.edu)].


==Giant cell tumour of tendon sheath==
==Giant cell tumour of tendon sheath==
Line 945: Line 959:
*#Fibrous/spindle cell component.
*#Fibrous/spindle cell component.
*#Epithelial component.
*#Epithelial component.
Images:
*[http://southbaypath.org/CaseImages/sb5260/AdamantinomaBiopsy3.jpg Adamantinoma (southbaypath.org)].<ref>URL: [http://southbaypath.org/CaseImages/sb5260/sb5260.htm http://southbaypath.org/CaseImages/sb5260/sb5260.htm]. Accessed on: 7 December 2010.</ref>
*[http://commons.wikimedia.org/wiki/File:Adamantinoma_-_intermed_mag.jpg Adamantinoma - intermed. mag. (WC)].


DDx:<ref name=pathcon_adam>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2]. Accessed on: 28 April 2011.</ref>
DDx:<ref name=pathcon_adam>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2]. Accessed on: 28 April 2011.</ref>
*Vascular tumours ([[Epithelioid hemangioendothelioma]]).
*Vascular tumours ([[Epithelioid hemangioendothelioma]]).
*Metastatic carcinoma.
*Metastatic carcinoma.
====Images====
<gallery>
Image:Adamantinoma_-_intermed_mag.jpg | Adamantinoma - intermed. mag. (WC)
</gallery>
www:
*[http://southbaypath.org/CaseImages/sb5260/AdamantinomaBiopsy3.jpg Adamantinoma (southbaypath.org)].<ref>URL: [http://southbaypath.org/CaseImages/sb5260/sb5260.htm http://southbaypath.org/CaseImages/sb5260/sb5260.htm]. Accessed on: 7 December 2010.</ref>


===IHC===
===IHC===
Line 988: Line 1,005:
*[[Giant cell tumour of bone]] and other [[giant cell lesions]].
*[[Giant cell tumour of bone]] and other [[giant cell lesions]].


Images:
====Images====
*www:
<gallery>
**[http://wwwold.path.utah.edu/classes/webpath/bonehtml/bone053.htm Brown tumour (utah.edu)].
Image:Brown_tumour_-_low_mag.jpg | Brown tumour - low mag. (WC)
**[http://www.mda-sy.com/pathology/BONEHTML/BONE054.HTM Brown tumour (mda-sy.com)].
Image:Brown_tumour_-_intermed_mag.jpg | Brown tumour - intermed. mag. (WC)
**[http://path.upmc.edu/cases/case139/micro.html Brown tumour - several images (upmc.edu)].
Image:Brown_tumour_-_high_mag.jpg | Brown tumour - high mag. (WC)
*[[WC]]:
</gallery>
**[http://commons.wikimedia.org/wiki/File:Brown_tumour_-_low_mag.jpg Brown tumour - low mag. (WC)].
www:
**[http://commons.wikimedia.org/wiki/File:Brown_tumour_-_intermed_mag.jpg Brown tumour - intermed. mag. (WC)].
*[http://wwwold.path.utah.edu/classes/webpath/bonehtml/bone053.htm Brown tumour (utah.edu)].
**[http://commons.wikimedia.org/wiki/File:Brown_tumour_-_high_mag.jpg Brown tumour - high mag. (WC)].
*[http://www.mda-sy.com/pathology/BONEHTML/BONE054.HTM Brown tumour (mda-sy.com)].
*[http://path.upmc.edu/cases/case139/micro.html Brown tumour - several images (upmc.edu)].


=See also=
=See also=
Retrieved from "https://librepathology.org/wiki/Chondro-osseous_tumours"