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Difference between revisions of "Vagina"
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Low grade pre-cancerous lesions of the vagina (VAIN) are typically [[HPV]] positive, while high grade pre-cancerous lesions and cancer are less often HPV positive.<ref name=pmid19115209>{{cite journal |author=De Vuyst H, Clifford GM, Nascimento MC, Madeleine MM, Franceschi S |title=Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis |journal=Int. J. Cancer |volume=124 |issue=7 |pages=1626–36 |year=2009 |month=April |pmid=19115209 |doi=10.1002/ijc.24116 |url=}}</ref> | Low grade pre-cancerous lesions of the vagina (VAIN) are typically [[HPV]] positive, while high grade pre-cancerous lesions and cancer are less often HPV positive.<ref name=pmid19115209>{{cite journal |author=De Vuyst H, Clifford GM, Nascimento MC, Madeleine MM, Franceschi S |title=Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis |journal=Int. J. Cancer |volume=124 |issue=7 |pages=1626–36 |year=2009 |month=April |pmid=19115209 |doi=10.1002/ijc.24116 |url=}}</ref> | ||
=Normal vagina= | |||
*Squamous epithelium, non-keratinized. | *Squamous epithelium, non-keratinized. | ||
==Prolapse== | ==Prolapse== | ||
*Pieces of vagina are often submitted in the context of uterine prolapse. | *Pieces of vagina are often submitted in the context of [[uterine prolapse]]. | ||
===Microscopic=== | ===Microscopic=== | ||
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*Squamous epithelium. | *Squamous epithelium. | ||
==Vaginal cancer | =Viral infections= | ||
===General=== | |||
*Cannot differentiate HSV1, HSV2, VZV using H&E.<ref name=herpes>URL: [http://missinglink.ucsf.edu/lm/DermatologyGlossary/herpes_simplex.html http://missinglink.ucsf.edu/lm/DermatologyGlossary/herpes_simplex.html]. Accessed on: 30 August 2011.</ref> | |||
===Microscopic=== | |||
Features:<ref name=herpes/> | |||
*Keratinocytes enlargement + acanthosis. | |||
**Intraepidermal vesicles & bullae. | |||
*Nuclear changes - 3 Ms: | |||
*#Moulding of nuclei. | |||
*#Margination of chromatin. | |||
*#Multinucleation. | |||
*Nuclei have "steel gray" colour. | |||
Images: | |||
*[http://missinglink.ucsf.edu/lm/DermatologyGlossary/img/Dermatology%20Glossary/Glossary%20Histo%20Images/herpes_high_power.jpg Herpes (ucsf.edu)]. | |||
*[http://missinglink.ucsf.edu/lm/DermatologyGlossary/img/Dermatology%20Glossary/Glossary%20Histo%20Images/herpes_low_power.jpg Herpes - skin (ucsf.edu)]. | |||
=Vaginal cancer= | |||
*[[Squamous cell carcinoma]] - most common cancer of the vagina. | *[[Squamous cell carcinoma]] - most common cancer of the vagina. | ||
**Precursor lesions are similar to the [[cervix]]<ref name=pmid18714572>{{cite journal |author=Indraccolo U, Chiocci L, Baldoni A |title=Does vaginal intraepithelial neoplasia have the same evolution as cervical intraepithelial neoplasia? |journal=Eur. J. Gynaecol. Oncol. |volume=29 |issue=4 |pages=371–3 |year=2008 |pmid=18714572 |doi= |url=}}</ref> and are often HPV associated - see ''vaginal intraepithelial neoplasia'' (VAIN). | **Precursor lesions are similar to the [[cervix]]<ref name=pmid18714572>{{cite journal |author=Indraccolo U, Chiocci L, Baldoni A |title=Does vaginal intraepithelial neoplasia have the same evolution as cervical intraepithelial neoplasia? |journal=Eur. J. Gynaecol. Oncol. |volume=29 |issue=4 |pages=371–3 |year=2008 |pmid=18714572 |doi= |url=}}</ref> and are often HPV associated - see ''vaginal intraepithelial neoplasia'' (VAIN). | ||
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The lamina propria/epithelial interface sampled is well-demarcated. | The lamina propria/epithelial interface sampled is well-demarcated. | ||
=See also= | |||
*[[Gynecologic pathology]]. | *[[Gynecologic pathology]]. | ||
*[[Uterus]]. | *[[Uterus]]. | ||
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*[[Vulva]]. | *[[Vulva]]. | ||
=References= | |||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Gynecologic pathology]] | [[Category:Gynecologic pathology]] | ||