Difference between revisions of "Pancreas"

Line 484:

*[http://commons.wikimedia.org/wiki/File:Pancreas_adenocarcinoma_(2)_Case_01.jpg Pancreatic adenocarcinoma (WC)].

*[http://commons.wikimedia.org/wiki/File:Pancreas_neoplasia_carcinoma_sequence.png Normal pancreas, pancreatic intraepithelial neoplasia and pancreatic carcinoma (WC)].

DDx:

*Chronic pancreatitis.<ref name=pmid16273946>{{Cite journal | last1 = Adsay | first1 = NV. | last2 = Bandyopadhyay | first2 = S. | last3 = Basturk | first3 = O. | last4 = Othman | first4 = M. | last5 = Cheng | first5 = JD. | last6 = Klöppel | first6 = G. | last7 = Klimstra | first7 = DS. | title = Chronic pancreatitis or pancreatic ductal adenocarcinoma? | journal = Semin Diagn Pathol | volume = 21 | issue = 4 | pages = 268-76 | month = Nov | year = 2004 | doi = | PMID = 16273946 }}</ref>

==Chronic pancreatitis==

===General===

*May be confused with ductal adenocarcinoma radiologically... and pathologically.

===Microscopic===

Features of benign:<ref name=pmid16273946>{{Cite journal | last1 = Adsay | first1 = NV. | last2 = Bandyopadhyay | first2 = S. | last3 = Basturk | first3 = O. | last4 = Othman | first4 = M. | last5 = Cheng | first5 = JD. | last6 = Klöppel | first6 = G. | last7 = Klimstra | first7 = DS. | title = Chronic pancreatitis or pancreatic ductal adenocarcinoma? | journal = Semin Diagn Pathol | volume = 21 | issue = 4 | pages = 268-76 | month = Nov | year = 2004 | doi = | PMID = 16273946 }}</ref>

*Preservation of lobular architecture - evenly spaced ductal units.

*Uniformly sized ductal elements.

*Smooth ductal contours.

*Ducts surrounded by acini or islets.

*Intraluminal mucoprotein plugs.

Features of adenocarcinoma:<ref name=pmid16273946>{{Cite journal | last1 = Adsay | first1 = NV. | last2 = Bandyopadhyay | first2 = S. | last3 = Basturk | first3 = O. | last4 = Othman | first4 = M. | last5 = Cheng | first5 = JD. | last6 = Klöppel | first6 = G. | last7 = Klimstra | first7 = DS. | title = Chronic pancreatitis or pancreatic ductal adenocarcinoma? | journal = Semin Diagn Pathol | volume = 21 | issue = 4 | pages = 268-76 | month = Nov | year = 2004 | doi = | PMID = 16273946 }}</ref>

*Random distribution of ductal structures,

*Irregular ductal contours,

*Nuclear atypia:

**Enlargement (>3 times the size of a lymphocyte).

**Pleomorphism.

**Distinct nucleoli.

*Intraluminal necrotic cellular debris.

*Hyperchromatic raisinoid nucleoli.

*"Naked ducts in fat"; ducts without surrounding pancreatic elements or fibrous tissue.

*Ducts adjacent to arterioles.

*Generally assoc. with malignancy:

**Perineural and vascular invasion (rare).

**Mitosis.

==See also==

Difference between revisions of "Pancreas"

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@@ Line 484: / Line 484: @@
 *[http://commons.wikimedia.org/wiki/File:Pancreas_adenocarcinoma_(2)_Case_01.jpg Pancreatic adenocarcinoma (WC)].
 *[http://commons.wikimedia.org/wiki/File:Pancreas_neoplasia_carcinoma_sequence.png Normal pancreas, pancreatic intraepithelial neoplasia and pancreatic carcinoma (WC)].
+DDx:
+*Chronic pancreatitis.<ref name=pmid16273946>{{Cite journal  | last1 = Adsay | first1 = NV. | last2 = Bandyopadhyay | first2 = S. | last3 = Basturk | first3 = O. | last4 = Othman | first4 = M. | last5 = Cheng | first5 = JD. | last6 = Klöppel | first6 = G. | last7 = Klimstra | first7 = DS. | title = Chronic pancreatitis or pancreatic ductal adenocarcinoma? | journal = Semin Diagn Pathol | volume = 21 | issue = 4 | pages = 268-76 | month = Nov | year = 2004 | doi =  | PMID = 16273946 }}</ref>
+==Chronic pancreatitis==
+===General===
+*May be confused with ductal adenocarcinoma radiologically... and pathologically.
+===Microscopic===
+Features of benign:<ref name=pmid16273946>{{Cite journal  | last1 = Adsay | first1 = NV. | last2 = Bandyopadhyay | first2 = S. | last3 = Basturk | first3 = O. | last4 = Othman | first4 = M. | last5 = Cheng | first5 = JD. | last6 = Klöppel | first6 = G. | last7 = Klimstra | first7 = DS. | title = Chronic pancreatitis or pancreatic ductal adenocarcinoma? | journal = Semin Diagn Pathol | volume = 21 | issue = 4 | pages = 268-76 | month = Nov | year = 2004 | doi =  | PMID = 16273946 }}</ref>
+*Preservation of lobular architecture - evenly spaced ductal units.
+*Uniformly sized ductal elements.
+*Smooth ductal contours.
+*Ducts surrounded by acini or islets.
+*Intraluminal mucoprotein plugs.
+Features of adenocarcinoma:<ref name=pmid16273946>{{Cite journal  | last1 = Adsay | first1 = NV. | last2 = Bandyopadhyay | first2 = S. | last3 = Basturk | first3 = O. | last4 = Othman | first4 = M. | last5 = Cheng | first5 = JD. | last6 = Klöppel | first6 = G. | last7 = Klimstra | first7 = DS. | title = Chronic pancreatitis or pancreatic ductal adenocarcinoma? | journal = Semin Diagn Pathol | volume = 21 | issue = 4 | pages = 268-76 | month = Nov | year = 2004 | doi =  | PMID = 16273946 }}</ref>
+*Random distribution of ductal structures,
+*Irregular ductal contours,
+*Nuclear atypia:
+**Enlargement (>3 times the size of a lymphocyte).
+**Pleomorphism.
+**Distinct nucleoli.
+*Intraluminal necrotic cellular debris.
+*Hyperchromatic raisinoid nucleoli.
+*"Naked ducts in fat"; ducts without surrounding pancreatic elements or fibrous tissue.
+*Ducts adjacent to arterioles.
+*Generally assoc. with malignancy:
+**Perineural and vascular invasion (rare).
+**Mitosis.
 ==See also==