Difference between revisions of "Testis"
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==Normal== | ==Normal== | ||
===Seminiferous tubules=== | |||
*Sertoli cells (aka sustentacular cell aka nurse cell). | *Sertoli cells (aka sustentacular cell aka nurse cell). | ||
**Large cells with oval nucleus. | **Large cells with oval nucleus. | ||
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*D2-40 - seminoma. | *D2-40 - seminoma. | ||
==Intratubular germ cell neoplasia== | |||
*Considered the precursor lesion for germ cell tumours. | |||
*Not all germ cell tumours (GCTs) arise from ''intratubular germ cell neoplasia''. | |||
The following testicular GCTs do not arise from ITCGN: | |||
*[[Spermatocytic seminoma]].<ref>{{cite journal |author=Müller J, Skakkebaek NE, Parkinson MC |title=The spermatocytic seminoma: views on pathogenesis |journal=Int. J. Androl. |volume=10 |issue=1 |pages=147–56 |year=1987 |month=February |pmid=3583416 |doi= |url=}}</ref> | |||
*[[Yolk sac tumour]]s (endodermal sinus tumour).<ref>{{cite journal |author=Manivel JC, Simonton S, Wold LE, Dehner LP |title=Absence of intratubular germ cell neoplasia in testicular yolk sac tumors in children. A histochemical and immunohistochemical study |journal=Arch. Pathol. Lab. Med. |volume=112 |issue=6 |pages=641–5 |year=1988 |month=June |pmid=2837162 |doi= |url=}}</ref> | |||
*Teratoma. (???) | |||
==Seminoma== | ==Seminoma== | ||
Male counterpart of the [[dysgerminoma]], which arise in the [[ovary]]. | *Male counterpart of the [[dysgerminoma]], which arise in the [[ovary]]. | ||
===Epi. & etiology=== | |||
*Arises from ''intratubular germ cell neoplasia'' (ITGCN). | |||
===Microsopy=== | ===Microsopy=== | ||
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*Solid variant of yolk sac tumour. | *Solid variant of yolk sac tumour. | ||
**Lacks fibrous septae and lymphocytes.<ref>URL: [http://webpathology.com/image.asp?case=34&n=8 http://webpathology.com/image.asp?case=34&n=8]. Accessed on: March 8, 2010.</ref> | **Lacks fibrous septae and lymphocytes.<ref>URL: [http://webpathology.com/image.asp?case=34&n=8 http://webpathology.com/image.asp?case=34&n=8]. Accessed on: March 8, 2010.</ref> | ||
===IHC=== | ===IHC=== | ||
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*CD30+ (??? check ???) | *CD30+ (??? check ???) | ||
*Cytokeratins - (weak focal positivity) | *Cytokeratins - (weak focal positivity) | ||
==Spermatocytic seminoma== | ==Spermatocytic seminoma== | ||
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===Epidemiology=== | ===Epidemiology=== | ||
*Does NOT arise from ''intratubular germ cell neoplasia'' (ITGCN)<ref>{{cite journal |author=Müller J, Skakkebaek NE, Parkinson MC |title=The spermatocytic seminoma: views on pathogenesis |journal=Int. J. Androl. |volume=10 |issue=1 |pages=147–56 |year=1987 |month=February |pmid=3583416 |doi= 10.1111/j.1365-2605.1987.tb00176.x|url=}}</ref> - '''not''' considered a subtype of seminoma. | *Does NOT arise from ''intratubular germ cell neoplasia'' (ITGCN)<ref>{{cite journal |author=Müller J, Skakkebaek NE, Parkinson MC |title=The spermatocytic seminoma: views on pathogenesis |journal=Int. J. Androl. |volume=10 |issue=1 |pages=147–56 |year=1987 |month=February |pmid=3583416 |doi= 10.1111/j.1365-2605.1987.tb00176.x|url=}}</ref> - '''not''' considered a subtype of seminoma. | ||
==Yolk sac tumour== | ==Yolk sac tumour== | ||