Difference between revisions of "Sjögren syndrome"
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*"Significant lymphocytic infiltrate" adjacent to viable [[salivary gland]] (or [[lacrimal gland]]) acini - '''key feature'''. | *"Significant lymphocytic infiltrate" adjacent to viable [[salivary gland]] (or [[lacrimal gland]]) acini - '''key feature'''. | ||
**"Significant" lymphocytic infiltrate": cluster of >= 50 lymphocytes - '''important'''. | **"Significant" lymphocytic infiltrate": cluster of >= 50 lymphocytes - '''important'''. | ||
***Lymphocytes may be perivascular or periductular.<ref name=pmid12022353/><ref name=pmid8003059/> | ***Lymphocytes may be perivascular or periductular.<ref name=pmid12022353/><ref name=pmid8003059>{{Cite journal | last1 = Daniels | first1 = TE. | last2 = Whitcher | first2 = JP. | title = Association of patterns of labial salivary gland inflammation with keratoconjunctivitis sicca. Analysis of 618 patients with suspected Sjögren's syndrome. | journal = Arthritis Rheum | volume = 37 | issue = 6 | pages = 869-77 | month = Jun | year = 1994 | doi = | PMID = 8003059 }}</ref> | ||
***[[Plasma cell]]s should not exceed 10% of the inflammatory infiltrate.<ref name=pmid12022353/> | ***[[Plasma cell]]s should not exceed 10% of the inflammatory infiltrate.<ref name=pmid12022353/> | ||
***May have "benign lymphoepithelial lesions"<ref name=pmid15956090/> - intraepithelial lymphocytes. | ***May have "benign lymphoepithelial lesions"<ref name=pmid15956090/> - intraepithelial lymphocytes. | ||