Difference between revisions of "Small cell lymphomas"

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*t(14;18)(q32;q21)/IGH-BCL2 in 70-95% of cases.<ref name=pmid18359244/>

**Should not be confused with t(14;18)(q32;q21)/IGH-MALT1 seen in MALT lymphomas.<ref name=pmid16950858>{{cite journal |author=Bacon CM, Du MQ, Dogan A |title=Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists |journal=J. Clin. Pathol. |volume=60 |issue=4 |pages=361–72 |year=2007 |month=April |pmid=16950858 |pmc=2001121 |doi=10.1136/jcp.2005.031146 |url=}}</ref>

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<pre>

RETROPERITONEAL MASS, RIGHT, CORE BIOPSIES:

- NON-HODGKIN B-CELL LYMPHOMA, FAVOUR FOLLICULAR LYMPHOMA.

COMMENT:

Morphology:

-Small cells: size ~ mature lymphocytes, quantity - many, angular and round.

-Large cells (intermixed with small cells): size ~1.5-2x mature lymphocyte,

small nucleoli, moderate quantity of grey/basophilic cytoplasm, moderate

nuclear pleomorphism.

-Architecture: no gland formation, discohesive, no follicles apparent, no sheets

of large cells.

-Mitoses are uncommon.

Immunohistochemical stains (tumour cells):

Positive: CD45 (strong, membranous/cytoplasmic), CD20 (strong, membranous/cytoplasmic),

BCL-2 (strong, membranous/cytoplasmic), CD10 (strong, membranous), BCL-6 (moderate,

patchy, nuclear).

Negative: pankeratin, CD3, CD5, CD30, CD21 (follicular dendritic cells not apparent),

CD23 (scattered, rare).

Ki-67: highlights the large cells, primarily -- 5-35% of cells within the core.

The findings favour a follicular lymphoma, based on the cellular morphology and

immunostains; however, they are limited by the type of tissue sampling (core biopsy).

Clinical correlation is suggested.

</pre>

==Mantle cell lymphoma==

Difference between revisions of "Small cell lymphomas"

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@@ Line 166: / Line 166: @@
 *t(14;18)(q32;q21)/IGH-BCL2 in 70-95% of cases.<ref name=pmid18359244/>
 **Should not be confused with t(14;18)(q32;q21)/IGH-MALT1 seen in MALT lymphomas.<ref name=pmid16950858>{{cite journal |author=Bacon CM, Du MQ, Dogan A |title=Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists |journal=J. Clin. Pathol. |volume=60 |issue=4 |pages=361–72 |year=2007 |month=April |pmid=16950858 |pmc=2001121 |doi=10.1136/jcp.2005.031146 |url=}}</ref>
+===Sign out===
+<pre>
+RETROPERITONEAL MASS, RIGHT, CORE BIOPSIES:
+- NON-HODGKIN B-CELL LYMPHOMA, FAVOUR FOLLICULAR LYMPHOMA.
+COMMENT:
+Morphology:
+-Small cells: size ~ mature lymphocytes, quantity - many, angular and round.
+-Large cells (intermixed with small cells): size ~1.5-2x mature lymphocyte,
+small nucleoli, moderate quantity of grey/basophilic cytoplasm, moderate
+nuclear pleomorphism.
+-Architecture: no gland formation, discohesive, no follicles apparent, no sheets
+of large cells.
+-Mitoses are uncommon.
+Immunohistochemical stains (tumour cells):
+Positive: CD45 (strong, membranous/cytoplasmic), CD20 (strong, membranous/cytoplasmic),
+BCL-2 (strong, membranous/cytoplasmic), CD10 (strong, membranous), BCL-6 (moderate,
+patchy, nuclear).
+Negative: pankeratin, CD3, CD5, CD30, CD21 (follicular dendritic cells not apparent),
+CD23 (scattered, rare).
+Ki-67: highlights the large cells, primarily -- 5-35% of cells within the core.
+The findings favour a follicular lymphoma, based on the cellular morphology and
+immunostains; however, they are limited by the type of tissue sampling (core biopsy).
+Clinical correlation is suggested.
+</pre>
 ==Mantle cell lymphoma==