Difference between revisions of "Prostate cancer"

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===Microscopic===

====Major criteria====

Required major criteria:<ref name=pmid22692290>{{Cite journal | last1 = Shah | first1 = RB. | last2 = Zhou | first2 = M. | title = Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. | journal = Adv Anat Pathol | volume = 19 | issue = 4 | pages = 270-8 | month = Jul | year = 2012 | doi = 10.1097/PAP.0b013e31825c6c0e | PMID = 22692290 }}</ref>

Required major criteria:<ref name=pmid22692290>{{Cite journal | last1 = Shah | first1 = RB. | last2 = Zhou | first2 = M. | title = Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. | journal = Adv Anat Pathol | volume = 19 | issue = 4 | pages = 270-8 | month = Jul | year = 2012 | doi = 10.1097/PAP.0b013e31825c6c0e | PMID = 22692290 }}</ref><ref name=pmid17616999>{{Cite journal | last1 = Cohen | first1 = RJ. | last2 = Wheeler | first2 = TM. | last3 = Bonkhoff | first3 = H. | last4 = Rubin | first4 = MA. | title = A proposal on the identification, histologic reporting, and implications of intraductal prostatic carcinoma. | journal = Arch Pathol Lab Med | volume = 131 | issue = 7 | pages = 1103-9 | month = Jul | year = 2007 | doi = 10.1043/1543-2165(2007)131[1103:APOTIH]2.0.CO;2 | PMID = 17616999 }}</ref>

#Glands 2x normal (peripheral zone) glands.

#Basal cell present (proven by IHC).

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#*Solid = no spaces between the cells.

Additional (major) ~~criterium~~:<ref name=pmid22692290/>

Additional (major) criterion:<ref name=pmid22692290/>

*Comedo[[necrosis]].

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#Rounded/smooth gland outlines.

#Two cell populations:

#*~~Enlarge~~ nuclei with hyperchromasia and nucleoli ~~(malignant~~) = peripheral.

#*Malignant population (enlarged nuclei with hyperchromasia and nucleoli) = peripheral location in gland.

#*~~Smaller~~ nuclei, no nucleoli ~~(benign~~) = central.

#*Benign population (smaller nuclei, no nucleoli) = central location in gland.

DDx:

Difference between revisions of "Prostate cancer"

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@@ Line 494: / Line 494: @@
 ===Microscopic===
 ====Major criteria====
-Required major criteria:<ref name=pmid22692290>{{Cite journal  | last1 = Shah | first1 = RB. | last2 = Zhou | first2 = M. | title = Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. | journal = Adv Anat Pathol | volume = 19 | issue = 4 | pages = 270-8 | month = Jul | year = 2012 | doi = 10.1097/PAP.0b013e31825c6c0e | PMID = 22692290 }}</ref>
+Required major criteria:<ref name=pmid22692290>{{Cite journal  | last1 = Shah | first1 = RB. | last2 = Zhou | first2 = M. | title = Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. | journal = Adv Anat Pathol | volume = 19 | issue = 4 | pages = 270-8 | month = Jul | year = 2012 | doi = 10.1097/PAP.0b013e31825c6c0e | PMID = 22692290 }}</ref><ref name=pmid17616999>{{Cite journal  | last1 = Cohen | first1 = RJ. | last2 = Wheeler | first2 = TM. | last3 = Bonkhoff | first3 = H. | last4 = Rubin | first4 = MA. | title = A proposal on the identification, histologic reporting, and implications of intraductal prostatic carcinoma. | journal = Arch Pathol Lab Med | volume = 131 | issue = 7 | pages = 1103-9 | month = Jul | year = 2007 | doi = 10.1043/1543-2165(2007)131[1103:APOTIH]2.0.CO;2 | PMID = 17616999 }}</ref>
 #Glands 2x normal (peripheral zone) glands.
 #Basal cell present (proven by IHC).
@@ Line 501: / Line 501: @@
 #*Solid = no spaces between the cells.
-Additional (major) criterium:<ref name=pmid22692290/>
+Additional (major) criterion:<ref name=pmid22692290/>
 *Comedo[[necrosis]].
@@ Line 509: / Line 509: @@
 #Rounded/smooth gland outlines.
 #Two cell populations:
-#*Enlarge nuclei with hyperchromasia and nucleoli (malignant) = peripheral.
+#*Malignant population (enlarged nuclei with hyperchromasia and nucleoli) = peripheral location in gland.
-#*Smaller nuclei, no nucleoli (benign) = central.
+#*Benign population (smaller nuclei, no nucleoli) = central location in gland.
 DDx: