Difference between revisions of "Dermatopathology"

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*Subdermis - below the dermis, connective tissue.
*Subdermis - below the dermis, connective tissue.


===Layers of the epidermis===
===Epidermis===
====Layers of the epidermis====
Epidermis layers - from the surface to epidermal-dermal junction:
Epidermis layers - from the surface to epidermal-dermal junction:
*Stratum corneum.  
*Stratum corneum.  
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====Cells of the epidermis====
====Cells of the epidermis====
*Keratinocytes.
*Keratinocytes.
**Usu. eosinophilic cytoplasm - '''important feature'''.
**Usually eosinophilic cytoplasm - '''important feature'''.
**May have clear perinuclear halo (glycogenated keratinocytes).
**May have clear perinuclear halo (glycogenated keratinocytes).
**Intercellular bridges (high power) - '''key feature'''.
**Intercellular bridges (high power) - '''key feature'''.
*Melanocytes.
*Melanocytes.
**Usu. basal location.
**Usuallly basal location.
**Epithelioid or dentritic morphology.
**Epithelioid or dentritic morphology.
**Pericellular clearing - '''key feature'''.
**Pericellular clearing - '''key feature'''.
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***[[Paget disease]]: large cells with clear cytoplasm, may cluster, above basal layer.
***[[Paget disease]]: large cells with clear cytoplasm, may cluster, above basal layer.


===Layers of the dermis===
====Normal histology====
Subdivided into:
Features:
*Keratinocytes:
**Basal ~ 2x [[RBC]].
***May palisade focally ~ 1:2 = width: height.
 
===Dermis===
Subdivided into layers:
#Papillary dermis.
#Papillary dermis.
#*Location: superficial - opposed to the deep aspect of the epidermis.
#*Location: superficial - opposed to the deep aspect of the epidermis.
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