Difference between revisions of "Fibroblastic/myofibroblastic tumours"

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(re-arr)
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*Beta-catenin +ve - '''important'''.
*Beta-catenin +ve - '''important'''.
*SMA +ve ~50% of lesions.
*SMA +ve ~50% of lesions.
==Low-grade myofibroblastic sarcoma==
===General===
*Rare ~ 100 cases in the literature.
*Usu. oral cavity or extremities.<ref name=pmid21868549/>
===Microscopic===
Features:
*Spindle cells in the storiform pattern<ref name=pmid21868549/> ''or'' in fasicles.
*Rare mitoses.
Images:
*[http://path.upmc.edu/cases/case673.html Low-grade myofibroblastic sarcoma - several images (upmc.edu)].
DDx:
*Atypical [[leiomyoma]].
*[[GIST]].
*[[Leiomyosarcoma]].
===IHC===
*SMA +ve.
*CD34 -ve.
*CD117 -ve.<ref name=pmid21868549/>
*H-caldesmon -ve.<ref name=pmid21868549>{{Cite journal  | last1 = Miyazawa | first1 = M. | last2 = Naritaka | first2 = Y. | last3 = Miyaki | first3 = A. | last4 = Asaka | first4 = S. | last5 = Isohata | first5 = N. | last6 = Yamaguchi | first6 = K. | last7 = Murayama | first7 = M. | last8 = Shimakawa | first8 = T. | last9 = Katsube | first9 = T. | title = A low-grade myofibroblastic sarcoma in the abdominal cavity. | journal = Anticancer Res | volume = 31 | issue = 9 | pages = 2989-94 | month = Sep | year = 2011 | doi =  | PMID =  }}</ref>


==Lipofibromatosis==
==Lipofibromatosis==
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===Molecular===
===Molecular===
*ALK rearrangements.<ref name=pmid21297584/>
*ALK rearrangements.<ref name=pmid21297584/>
==Low-grade myofibroblastic sarcoma==
===General===
*Rare ~ 100 cases in the literature.
*Usu. oral cavity or extremities.<ref name=pmid21868549/>
===Microscopic===
Features:
*Spindle cells in the storiform pattern<ref name=pmid21868549/> ''or'' in fasicles.
*Rare mitoses.
Images:
*[http://path.upmc.edu/cases/case673.html Low-grade myofibroblastic sarcoma - several images (upmc.edu)].
DDx:
*Atypical [[leiomyoma]].
*[[GIST]].
*[[Leiomyosarcoma]].
===IHC===
*SMA +ve.
*CD34 -ve.
*CD117 -ve.<ref name=pmid21868549/>
*H-caldesmon -ve.<ref name=pmid21868549>{{Cite journal  | last1 = Miyazawa | first1 = M. | last2 = Naritaka | first2 = Y. | last3 = Miyaki | first3 = A. | last4 = Asaka | first4 = S. | last5 = Isohata | first5 = N. | last6 = Yamaguchi | first6 = K. | last7 = Murayama | first7 = M. | last8 = Shimakawa | first8 = T. | last9 = Katsube | first9 = T. | title = A low-grade myofibroblastic sarcoma in the abdominal cavity. | journal = Anticancer Res | volume = 31 | issue = 9 | pages = 2989-94 | month = Sep | year = 2011 | doi =  | PMID =  }}</ref>


==Congenital-infantile fibrosarcoma==
==Congenital-infantile fibrosarcoma==
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