Difference between revisions of "Gestational trophoblastic disease"
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(→Complete hydatidiform mole: +gross descript.) |
(→IHC: tweak) |
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===IHC=== | ===IHC=== | ||
*p57(KIP2) - the gene is strongly paternally imprinted and the paternal copy is inactived; its expression is from the maternal gene. | *p57(KIP2) - the gene is strongly paternally imprinted and the paternal copy is inactived; its expression is from the maternal gene. | ||
**Complete moles | **Complete moles lack the maternal genome; thus, p57(KIP2) immunostaining (in the cytotrophoblasts and villous stromal cells) is absent.<ref name=pmid15754295>{{cite journal |author=Merchant SH, Amin MB, Viswanatha DS, Malhotra RK, Moehlenkamp C, Joste NE |title=p57KIP2 immunohistochemistry in early molar pregnancies: emphasis on its complementary role in the differential diagnosis of hydropic abortuses |journal=Hum. Pathol. |volume=36 |issue=2 |pages=180–6 |year=2005 |month=February |pmid=15754295 |doi=10.1016/j.humpath.2004.12.007 |url=}}</ref><ref name=pmid12514787>{{Cite journal | last1 = Fukunaga | first1 = M. | title = Immunohistochemical characterization of p57(KIP2) expression in early hydatidiform moles. | journal = Hum Pathol | volume = 33 | issue = 12 | pages = 1188-92 | month = Dec | year = 2002 | doi = 10.1053/hupa.2002.129421 | PMID = 12514787 }}</ref> | ||
***Intermediate trophoblasts and maternal tissue are positive controls.<ref name=pmid12514787/> | |||
**Memory device: | **Memory device: | ||
***'''''p'''57 is '''p'''ositive in '''p'''artial moles''. | ***'''''p'''57 is '''p'''ositive in '''p'''artial moles''. | ||