Difference between revisions of "Pulmonary cytopathology"
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(→Adenocarcinoma: re-arr) |
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===Cytology=== | ===Cytology=== | ||
Features: | Features: | ||
*Eccentric nucleus: | |||
**+/-Nuclear grooves. | |||
**+/-Nuclear pseudoinclusions. | |||
*Nucleolus. | *Nucleolus. | ||
**Good ones are visible with 10X objective (virtually excludes SCLC). | **Good ones are visible with 10X objective (virtually excludes SCLC). | ||
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*Abundant cytoplasm - virtually excludes small cell carcinoma. | *Abundant cytoplasm - virtually excludes small cell carcinoma. | ||
*Vacuoles with mucin (pink discolouration) - virtually diagnostic. | *Vacuoles with mucin (pink discolouration) - virtually diagnostic. | ||
Notes: | Notes: | ||
*May be subtle, i.e. have minimal cytologic changes. | *May be subtle, i.e. have minimal cytologic changes. | ||
*No nuclear moulding -esp. important if no nucleolus visible. | |||
DDx: | DDx: | ||
*[[Creola body]] - have cilia, may be subtle. | |||
*Benign mesothelium (also sheets of cells). | *Benign mesothelium (also sheets of cells). | ||
*Atypical adenomatous hyperplasia (AAH) - thought to be the precursor to adenocarcinoma.<ref name=pmid11235908>{{Cite journal | last1 = Mori | first1 = M. | last2 = Rao | first2 = SK. | last3 = Popper | first3 = HH. | last4 = Cagle | first4 = PT. | last5 = Fraire | first5 = AE. | title = Atypical adenomatous hyperplasia of the lung: a probable forerunner in the development of adenocarcinoma of the lung. | journal = Mod Pathol | volume = 14 | issue = 2 | pages = 72-84 | month = Feb | year = 2001 | doi = 10.1038/modpathol.3880259 | PMID = 11235908 |url = http://www.nature.com/modpathol/journal/v14/n2/full/3880259a.html }}</ref> | *Atypical adenomatous hyperplasia (AAH) - thought to be the precursor to adenocarcinoma.<ref name=pmid11235908>{{Cite journal | last1 = Mori | first1 = M. | last2 = Rao | first2 = SK. | last3 = Popper | first3 = HH. | last4 = Cagle | first4 = PT. | last5 = Fraire | first5 = AE. | title = Atypical adenomatous hyperplasia of the lung: a probable forerunner in the development of adenocarcinoma of the lung. | journal = Mod Pathol | volume = 14 | issue = 2 | pages = 72-84 | month = Feb | year = 2001 | doi = 10.1038/modpathol.3880259 | PMID = 11235908 |url = http://www.nature.com/modpathol/journal/v14/n2/full/3880259a.html }}</ref> | ||
**AAH has a size criterion, ergo not really possible to diagnose on cytopathology specimen. | **AAH has a size criterion, ergo not really possible to diagnose on cytopathology specimen. | ||
==Neuroendocrine tumours== | ==Neuroendocrine tumours== | ||