Difference between revisions of "Lymphoma"

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*CD45 +ve. (???)
*CD45 +ve. (???)


==Table of B-cell lymphoma==
==Table of lymphoma==
Small cell lymphomas:
Lymphomas:
{| class="wikitable"
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
! Name
! Name
! Location
! Size of cells
! Size of cells
! Site
! Histomorphology
! IHC
! IHC
! Translocations
! Translocations
! Clinical
! Clinical
! Other
! Prevalence
! DDx
|-
|-
| Follicular lymphoma
| Follicular lymphoma
| Follicle
| small (centrocytes)
| Small, centrocytes, centroblasts
| lymph node, germinal center
| abundant atypical follicles (lack GC polarity, lack polar mantle zone), effaced sinuses, scattered large cells (centroblasts)
| CD10+, bcl-6+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| CD10+, bcl-6+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| t(14,18)
| t(14,18)
| Clinical ?
| usually indolent, may transform to DLBCL
| Other ?
| very common
| DLBCL, other small cell lymphomas
|-
|-
| Mantle cell lymphoma
| Mantle cell lymphoma
| Mantle zone
| small, monomorphic
| Small
| lymph node, mantle zone
| monomorphic lymphoid, abundant mitoses. +/-scattered epithelioid histiocytes, sclerosed blood vessels
| CD5+, CD23-, CD43+, cyclin D1+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| CD5+, CD23-, CD43+, cyclin D1+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| t(11;14)(q13;q32)<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref>
| t(11;14)(q13;q32)<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref>
| Clinical ?
| indolent ???
| Other ?
| uncommon
| other small cell lymphomas, PTGC, Castleman disease, Burkitt's lymphoma
|-
|-
| Marginal zone lymphoma (MALT)
| Extranodal marginal zone lymphoma (MALT lymphoma)
| Marginal zone
| small
| Small
| mucosa-associated lymphoid tissue, GI tract + elsewhere
| +/- lymphepithelial lesion (cluster of 3+ cells in epithelium)
| CD21+, CD11c+, CD5-, CD23-<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| CD21+, CD11c+, CD5-, CD23-<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| Translocations
| ???
| Clinical
| indolent ???
| Other
| common
| other small cell lymphomas, neuroendocrine tumours
|-
|-
| Precursor lymphoblastic lymphoma/leukemia
| Precursor lymphoblastic lymphoma/ leukemia
| Location ?
| small
| Small
| lymph node ???
| ???
| CD10+, CD5-, TdT+, CD99+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| CD10+, CD5-, TdT+, CD99+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref>
| Translocations ?
| translocations ???
| Clinical ?
| aggressive ???
| Other ?
| uncommon
|}
| small cell lymphomas
 
Medium and large cell lymphomas:
{| class="wikitable"
! Name
! Location
! Size of cells
! IHC
! Translocations
! Clinical
! Other
|-
|-
| Burkitt's lymphoma
| Burkitt's lymphoma
| Follicle
| medium, monomorphic
| Large cells
| lymph node, germinal center (???)
| CD10, bcl-6
| tingible-body macrophages ("starry sky" appearance), round nucleus, small nucleoli, mitoses +++
| CD10+, BCL6+, BCL2-
| t(8;14) (q24;q32)  
| t(8;14) (q24;q32)  
| Rapid growth
| rapid growth, may be associated with EBV, HIV/AIDS
| "Starry sky"
| uncommon
| DLBCL, mantle cell lymphoma
|-
|-
| Diffuse large B cell lymphoma
| Diffuse large B cell lymphoma
| Follicle (?)
| large cells (>2x RBC, often larger), variable size
| Large 4-5X of lymphocyte
| lymph node usually, germinal center
| sheets of large discohesive cells; if only nodular = follicular lymphoma
| MIB-1 >40%
| MIB-1 >40%
| none/like follicular l.
| none / like follicular lymphoma t(14,18) / c-MYC (like Burkitt lymphoma)
| Poor prognosis
| poor prognosis
| Common among lymphomas
| common among lymphomas
|-
| Burkitt lymphoma, ALCL, Hodgkin lymphoma
|- <!--
| Name
| Name
| Location
| size of cells ?
| Size of cells
| site ?
| IHC
| histomorphology ?
| Translocations
| IHC ?
| Clinical
| translocations ?
| Other
| clinical ?
| prevalence ?
| DDx ? -->
|}
|}


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