Difference between revisions of "Hodgkin lymphoma"

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Notes:
Notes:
*Large mononuclear cells are common (so called "mononuclear RSCs") but not diagnostic.
*Large mononuclear cells are common (so called "mononuclear RSCs") but not diagnostic.
DDx:
*[[Diffuse large B cell lymphoma]] (DLBCL).
*[[Anaplastic large cell lymphoma]] (ALCL).


Images (classic HL):
Images (classic HL):
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**Lobulated nucleus - '''key feature'''.
**Lobulated nucleus - '''key feature'''.
**Small nucleoli.  
**Small nucleoli.  
*Subtle nodularity at low power (2.5x or 5x objective).


Images (NLPHL):  
Images (NLPHL):  
*[http://webpathology.com/image.asp?case=388&n=16 Popcorn cell (webpathology.com)].
*[http://webpathology.com/image.asp?case=388&n=16 Popcorn cell (webpathology.com)].
*[http://commons.wikimedia.org/wiki/File:Popcorn_cell_in_nodular_lymphocyte_predominant_Hodgkin_lymphoma_-_very_high_mag_cropped.jpg Popcorn cell (WC)].
*[http://commons.wikimedia.org/wiki/File:Popcorn_cell_in_nodular_lymphocyte_predominant_Hodgkin_lymphoma_-_very_high_mag_cropped.jpg Popcorn cell (WC)].
===DDx both CHL & NLPHL===
*CHL/NLPHL.
*[[Diffuse large B cell lymphoma]] (DLBCL).
*[[Anaplastic large cell lymphoma]] (ALCL).


==IHC==
==IHC==