Difference between revisions of "Breast cytopathology"

Line 70:

==Fat [[necrosis]]==

Features:

*Dying adipocytes - pink low density whispy poorly demarcated blobs, lack nucleus.

===Microscopic===

**~~Healthy~~ adipocytes ~~- large cells, clear cytoplasm~~.

Features:<ref name=pmid19234281>{{Cite journal | last1 = Taboada | first1 = JL. | last2 = Stephens | first2 = TW. | last3 = Krishnamurthy | first3 = S. | last4 = Brandt | first4 = KR. | last5 = Whitman | first5 = GJ. | title = The many faces of fat necrosis in the breast. | journal = AJR Am J Roentgenol | volume = 192 | issue = 3 | pages = 815-25 | month = Mar | year = 2009 | doi = 10.2214/AJR.08.1250 | PMID = 19234281 | URL = http://www.ajronline.org/content/192/3/815.full }}</ref>

*Foamy macrophages - adjacent to fat.

*Dying/dead adipocytes:

**Abundant cytoplasm - with granular crap inside.

**Light pink "low density" whispy poorly demarcated blobs - lack a nucleus.

**Oval nucleus with small nucleolus.

***Early: cellular outlines seen, light pink - loose.

***Mid: adipocytes collapsed/more dense.

****Foamy macrophages - adjacent to fat.

*****Abundant cytoplasm - with granular (pink) crap inside.

*****Oval nucleus with small nucleolus.

***Late:

****Macrophages: multinucleated giant-cells.

****Calcification.

Notes:

*Healthy adipocytes - large cells, clear cytoplasm.

Images:

*[http://www.ajronline.org/content/192/3/815/F1.expansion.html Early fat necrosis (ajronline.org)].

*[http://www.ajronline.org/content/192/3/815/F4.expansion.html Mid fat necrosis (ajronline.org)].

*[http://www.ajronline.org/content/192/3/815/F5.expansion.html Late fat necrosis (ajronline.org)].

*[http://www.ajronline.org/content/192/3/815/F6.expansion.html Late fat necrosis - calcifications (ajronline.org)].

==Adenocarcinoma==

Difference between revisions of "Breast cytopathology"

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@@ Line 70: / Line 70: @@
 ==Fat [[necrosis]]==
-Features:
-*Dying adipocytes - pink low density whispy poorly demarcated blobs, lack nucleus.
+===Microscopic===
-**Healthy adipocytes - large cells, clear cytoplasm.
+Features:<ref name=pmid19234281>{{Cite journal  | last1 = Taboada | first1 = JL. | last2 = Stephens | first2 = TW. | last3 = Krishnamurthy | first3 = S. | last4 = Brandt | first4 = KR. | last5 = Whitman | first5 = GJ. | title = The many faces of fat necrosis in the breast. | journal = AJR Am J Roentgenol | volume = 192 | issue = 3 | pages = 815-25 | month = Mar | year = 2009 | doi = 10.2214/AJR.08.1250 | PMID = 19234281 | URL = http://www.ajronline.org/content/192/3/815.full }}</ref>
-*Foamy macrophages - adjacent to fat.
+*Dying/dead adipocytes:
-**Abundant cytoplasm - with granular crap inside.
+**Light pink "low density" whispy poorly demarcated blobs - lack a nucleus.
-**Oval nucleus with small nucleolus.
+***Early: cellular outlines seen, light pink - loose.
+***Mid: adipocytes collapsed/more dense.
+****Foamy macrophages - adjacent to fat.
+*****Abundant cytoplasm - with granular (pink) crap inside.
+*****Oval nucleus with small nucleolus.
+***Late:
+****Macrophages: multinucleated giant-cells.
+****Calcification.
+Notes:
+*Healthy adipocytes - large cells, clear cytoplasm.
+Images:
+*[http://www.ajronline.org/content/192/3/815/F1.expansion.html Early fat necrosis (ajronline.org)].
+*[http://www.ajronline.org/content/192/3/815/F4.expansion.html Mid fat necrosis (ajronline.org)].
+*[http://www.ajronline.org/content/192/3/815/F5.expansion.html Late fat necrosis (ajronline.org)].
+*[http://www.ajronline.org/content/192/3/815/F6.expansion.html Late fat necrosis - calcifications (ajronline.org)].
 ==Adenocarcinoma==