Difference between revisions of "NUT carcinoma"

From Libre Pathology
Jump to navigation Jump to search
(+cat. dx)
Line 24: Line 24:
*Rearrangement of the ''NUT'' gene.<ref name=pmid20951314/>
*Rearrangement of the ''NUT'' gene.<ref name=pmid20951314/>
**Most common: t(15;19)(q14;p13) ''BRD/NUT''.<ref name=pmid18552174>{{Cite journal  | last1 = French | first1 = CA. | title = Demystified molecular pathology of NUT midline carcinomas. | journal = J Clin Pathol | volume = 63 | issue = 6 | pages = 492-6 | month = Jun | year = 2010 | doi = 10.1136/jcp.2007.052902 | PMID = 18552174 }}</ref><ref>{{OMIM|608749}}</ref>
**Most common: t(15;19)(q14;p13) ''BRD/NUT''.<ref name=pmid18552174>{{Cite journal  | last1 = French | first1 = CA. | title = Demystified molecular pathology of NUT midline carcinomas. | journal = J Clin Pathol | volume = 63 | issue = 6 | pages = 492-6 | month = Jun | year = 2010 | doi = 10.1136/jcp.2007.052902 | PMID = 18552174 }}</ref><ref>{{OMIM|608749}}</ref>
==See also==
*[[Head and neck pathology]].
*[[Mediastinum]].
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 19:58, 15 November 2011

NUT midline carcinoma is a super rare tumour.

General

  • Not specific to any tissue type or organ.[1]
  • Defined by mutation in NUT gene.
    • NUT = Nuclear protein in testis.[2]

Clinical:

  • Usually midline - as the name of the tumour suggests.
  • Head, neck and mediastinum.[3]
  • Poor prognosis.

Microscopic

Features:[1][3]

  • Poorly differentiated carcinoma.
    • Cohesive malignant cells.
  • Islands of well-differentiated squamous epithelium - key feature.

DDx:

Molecular

  • Rearrangement of the NUT gene.[1]
    • Most common: t(15;19)(q14;p13) BRD/NUT.[3][4]

See also

References

  1. 1.0 1.1 1.2 French, CA. (Nov 2010). "NUT midline carcinoma.". Cancer Genet Cytogenet 203 (1): 16-20. doi:10.1016/j.cancergencyto.2010.06.007. PMID 20951314.
  2. Online 'Mendelian Inheritance in Man' (OMIM) 608963
  3. 3.0 3.1 3.2 French, CA. (Jun 2010). "Demystified molecular pathology of NUT midline carcinomas.". J Clin Pathol 63 (6): 492-6. doi:10.1136/jcp.2007.052902. PMID 18552174.
  4. Online 'Mendelian Inheritance in Man' (OMIM) 608749