Difference between revisions of "Hypersensitivity"
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==Gell & Goombs classification== | ==Gell & Goombs classification== | ||
{|Class="wikitable" | {|Class="wikitable" | ||
! Type (I-IV) | ! Type (I-IV) | ||
! Formal name<ref>{{Ref PCPBoD8|110}}</ref> | |||
! Name | ! Name | ||
! Example | ! Example | ||
! | ! Mediator | ||
! Pathology | |||
|- | |- | ||
| I | | I | ||
| | | Immediate h. | ||
| | | Allergic h. | ||
| | | [[anaphylaxis]], (atopic) bronchial [[asthma]], allergies | ||
| IgE | |||
| mast cells, inflammation (esp. eosinophils), edema | |||
|- | |- | ||
| II | | II | ||
| Cytotoxic antibody dependent | | Antibody mediated h. | ||
| | | Cytotoxic antibody dependent h. | ||
| | | [[Goodpasture syndrome]] | ||
| antibodies (IgG, IgM) | |||
| (antibody-mediated) phagocytosis & lysis | |||
|- | |- | ||
| III | | III | ||
| Immune complex | | Immune complex mediated h. | ||
| | | Immune complex mediated h. | ||
| | | [[systemic lupus erythematosus]] | ||
| antigen-antibody complex | |||
| inflammation, [[vasculitis]] with [[fibrinoid necrosis]] | |||
|- | |- | ||
| IV | | IV | ||
| Cell-mediated h. | |||
| Delayed-type hypersensitivity | | Delayed-type hypersensitivity | ||
| | | tuberculosis | ||
| | | activated T cells | ||
| perivascular inflammation, [[granuloma]]s | |||
|} | |} | ||
Memory device ''ACID'':<ref>URL: [http://www.saintcyr.com/2001/mnemonic.html http://www.saintcyr.com/2001/mnemonic.html]. Accessed on: 13 November 2011.</ref> | |||
*Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity. | |||
==See also== | ==See also== | ||
*[[Hypersensitivity pneumonitis]]. | *[[Hypersensitivity pneumonitis]]. | ||
Revision as of 18:49, 13 November 2011
Hypersensitivity is a thingy one may get quized on.
Gell & Goombs classification
| Type (I-IV) | Formal name[1] | Name | Example | Mediator | Pathology |
|---|---|---|---|---|---|
| I | Immediate h. | Allergic h. | anaphylaxis, (atopic) bronchial asthma, allergies | IgE | mast cells, inflammation (esp. eosinophils), edema |
| II | Antibody mediated h. | Cytotoxic antibody dependent h. | Goodpasture syndrome | antibodies (IgG, IgM) | (antibody-mediated) phagocytosis & lysis |
| III | Immune complex mediated h. | Immune complex mediated h. | systemic lupus erythematosus | antigen-antibody complex | inflammation, vasculitis with fibrinoid necrosis |
| IV | Cell-mediated h. | Delayed-type hypersensitivity | tuberculosis | activated T cells | perivascular inflammation, granulomas |
Memory device ACID:[2]
- Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity.
See also
References
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 110. ISBN 978-1416054542.
- ↑ URL: http://www.saintcyr.com/2001/mnemonic.html. Accessed on: 13 November 2011.