Difference between revisions of "Thrombotic microangiopathy"
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*[[Thrombotic thrombocytopenic purpura]] (TTP). | *[[Thrombotic thrombocytopenic purpura]] (TTP). | ||
Others: | Others:<ref name=pmid20186056>{{Cite journal | last1 = Benz | first1 = K. | last2 = Amann | first2 = K. | title = Thrombotic microangiopathy: new insights. | journal = Curr Opin Nephrol Hypertens | volume = 19 | issue = 3 | pages = 242-7 | month = May | year = 2010 | doi = 10.1097/MNH.0b013e3283378f25 | PMID = 20186056 }}</ref> | ||
*[[Malignant hypertension]]. | *[[Malignant hypertension]]. | ||
*[[DIC]]. | *[[DIC]]. | ||
*[[APLA]] in [[SLE]]. | *[[APLA]]<ref>{{Cite journal | last1 = Asherson | first1 = RA. | title = The catastrophic antiphospholipid syndrome, 1998. A review of the clinical features, possible pathogenesis and treatment. | journal = Lupus | volume = 7 Suppl 2 | issue = | pages = S55-62 | month = | year = 1998 | doi = | PMID = 9814675 }}</ref> in [[SLE]]. | ||
*[[Scleroderma]] renal crisis. | *[[Scleroderma]] renal crisis. | ||
*[[HIV]] associated TTP. | *[[HIV]] associated TTP. | ||
Revision as of 03:22, 10 November 2011
Thrombotic microangiopathy is a group of disorders affecting small blood vessels. Microangiopathic is a disease affecting small blood vessels.[1]
Differential diagnosis
Others:[4]
- Malignant hypertension.
- DIC.
- APLA[5] in SLE.
- Scleroderma renal crisis.
- HIV associated TTP.
- Chemotherapy.
- Calcineurin inhibitor toxicity.
Notes:
- The above cannot be differentiated on a histomorphologic basis.
General
- Underlying pathology: endothelial cell damage.
Microscopic
Features:[6]
- Microvascular occlusion.[7]
- "Loose" intimal thickening; fluffy appearing intima.
- May be have an onion skin-like appearance.
- Fibrin entrapped RBCs.
Notes:
- The last two (#2 and #3) are useful for discrimination from endarteritis.[6]
- Early finding: endothelial cell swelling.
Image:
See also
References
- ↑ URL: http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm. Accessed on: 9 September 2010.
- ↑ URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 November 2010.
- ↑ Mayer SA, Aledort LM (May 2005). "Thrombotic microangiopathy: differential diagnosis, pathophysiology and therapeutic strategies". Mt. Sinai J. Med. 72 (3): 166–75. PMID 15915311.
- ↑ Benz, K.; Amann, K. (May 2010). "Thrombotic microangiopathy: new insights.". Curr Opin Nephrol Hypertens 19 (3): 242-7. doi:10.1097/MNH.0b013e3283378f25. PMID 20186056.
- ↑ Asherson, RA. (1998). "The catastrophic antiphospholipid syndrome, 1998. A review of the clinical features, possible pathogenesis and treatment.". Lupus 7 Suppl 2: S55-62. PMID 9814675.
- ↑ 6.0 6.1 Fogo, Agnes; Bruijn, Jan A.; Cohen, Arthur H.; Colvin, Robert B.;Jennette, J. Charles (2006). Fundamentals of Renal Pathology (1st ed.). Springer. pp. 204. ISBN 978-0387311265.
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 670. ISBN 978-1416031215.
- ↑ Ruggenenti, P.; Noris, M.; Remuzzi, G. (Sep 2001). "Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura.". Kidney Int 60 (3): 831-46. doi:10.1046/j.1523-1755.2001.060003831.x. PMID 11532079.