Difference between revisions of "Mastocytosis"
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# | '''Mastocytosis''' is the abundance of [[mast cells]]. | ||
==General== | |||
*Abundance of [[mast cell]]s. | |||
Classification:<ref name=pmid21083038>{{Cite journal | last1 = Arock | first1 = M. | last2 = Valent | first2 = P. | title = Pathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives. | journal = Expert Rev Hematol | volume = 3 | issue = 4 | pages = 497-516 | month = Aug | year = 2010 | doi = 10.1586/ehm.10.42 | PMID = 21083038 }}</ref> | |||
#Cutaneous (only) - usually children. | |||
#*Urticaria pigmentosa. | |||
#*Others. | |||
#Systemic - usually adults. | |||
#*Indolent subvariant. | |||
#*Aggressive subvariant. | |||
#*Leukemic subvariant. | |||
==Microscopic== | |||
Features:<ref name=Ref_PBoD8|1185>{{Ref PBoD8|1185}}</ref> | |||
*Cells in the superficial/mid dermis that are: | |||
**Lymphocyte-like with more cytoplasm that is granular. | |||
***Cells may have spindled or stellate morphology. | |||
***Tend to be more abundant around vessels. | |||
*+/-Eosinophils (common). | |||
*+/-Edema - often prominent; gives cells a white halo. | |||
Notes: | |||
*Lymphocyte vs. mast cell: | |||
**Lymphocytes = round; mast cells = ovoid. | |||
===Images=== | |||
www: | |||
*[http://www.jameswpattersonmd.com/case_studies/index.cfm?CFID=387434 Mastocytosis - low res. (jameswpattersonmd.com)]. | |||
*[http://path.upmc.edu/cases/case366.html Mastocytosis - bone marrow - several images (upmc.edu)]. | |||
*[http://path.upmc.edu/cases/case409.html Systemic mastocytosis - several images (upmc.edu)]. | |||
<gallery> | |||
Image:Mastocytosis_-_high_mag.jpg | Mastocytosis - high mag. (WC) | |||
Image:Mastocytosis_-_cropped_-_very_high_mag.jpg | Mastocytosis - very high mag. (WC) | |||
</gallery> | |||
==Stains== | |||
*[[Toluidine blue stain|Toluidine blue]] -- highlights the granules. | |||
==IHC== | |||
*CD117 +ve. | |||
*Tryptase +ve.<ref name=pmid21866466>{{Cite journal | last1 = Rudzki | first1 = Z. | last2 = Sotlar | first2 = K. | last3 = Kudela | first3 = A. | last4 = Starzak-Gwóźdź | first4 = J. | last5 = Horny | first5 = HP. | title = Systemic mastocytosis (SM) and associated malignant bone marrow histiocytosis - a hitherto undescribed form of SM-AHNMD. | journal = Pol J Pathol | volume = 62 | issue = 2 | pages = 101-4 | month = | year = 2011 | doi = | PMID = 21866466 }} | |||
</ref> | |||
==See also== | |||
*[[Non-malignant skin disease]]. | |||
*[[Mast cell]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Non-malignant skin disease]] | |||
Revision as of 04:56, 31 December 2013
Mastocytosis is the abundance of mast cells.
General
- Abundance of mast cells.
Classification:[1]
- Cutaneous (only) - usually children.
- Urticaria pigmentosa.
- Others.
- Systemic - usually adults.
- Indolent subvariant.
- Aggressive subvariant.
- Leukemic subvariant.
Microscopic
Features:[2]
- Cells in the superficial/mid dermis that are:
- Lymphocyte-like with more cytoplasm that is granular.
- Cells may have spindled or stellate morphology.
- Tend to be more abundant around vessels.
- Lymphocyte-like with more cytoplasm that is granular.
- +/-Eosinophils (common).
- +/-Edema - often prominent; gives cells a white halo.
Notes:
- Lymphocyte vs. mast cell:
- Lymphocytes = round; mast cells = ovoid.
Images
www:
- Mastocytosis - low res. (jameswpattersonmd.com).
- Mastocytosis - bone marrow - several images (upmc.edu).
- Systemic mastocytosis - several images (upmc.edu).
Mastocytosis - high mag. (WC)
Mastocytosis - very high mag. (WC)
Stains
- Toluidine blue -- highlights the granules.
IHC
- CD117 +ve.
- Tryptase +ve.[3]
See also
References
- ↑ Arock, M.; Valent, P. (Aug 2010). "Pathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives.". Expert Rev Hematol 3 (4): 497-516. doi:10.1586/ehm.10.42. PMID 21083038.
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1185. ISBN 978-1416031215.
- ↑ Rudzki, Z.; Sotlar, K.; Kudela, A.; Starzak-Gwóźdź, J.; Horny, HP. (2011). "Systemic mastocytosis (SM) and associated malignant bone marrow histiocytosis - a hitherto undescribed form of SM-AHNMD.". Pol J Pathol 62 (2): 101-4. PMID 21866466.