Difference between revisions of "Dermatopathic lymphadenopathy"
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'''Dermatopathic lymphadenopathy''' is a rare [[lymph node pathology|pathology of the lymph nodes]]. | |||
==General== | |||
*Lymphadenopathy associated with a skin lesion - '''key feature'''. | |||
*May be benign ''or'' malignant (e.g. T-cell lymphoma). | |||
==Microscopic== | |||
Features:<ref name=ILNP226>{{Ref ILNP|226}}</ref> | |||
*Abundant histiocytes & special histiocytes - in loose irregular clusters - located in the sinuses, i.e. sinus histiocytosis - '''key feature''': | |||
**Do ''not'' form granuloma; may be similar to ''toxoplasma''. | |||
*Plasma cells (medulla). | |||
*Eosinophils. | |||
Histiocytes & special histiocytes: | |||
*Histiocytes: | |||
**+/-Melanin pigment '''key feature''' (if present). | |||
**Lipid-laden macrophages. | |||
*Interdigitating dendritic cells: | |||
**Need IHC to identify definitively. | |||
*Langerhans cells: | |||
**Classically have a kidney bean nuclei. | |||
**Need IHC to identify definitively. | |||
DDx: | |||
*[[Metastatic]] [[malignant melanoma]] - (melanin) pigmented cells have nuclear atypia, not histiocytes. | |||
*[[Sinus histiocytosis]] - no cells with melanin. | |||
===Images=== | |||
<gallery> | |||
Image:Dermatopathic_lymphadenopathy_-_very_low_mag.jpg | DL - very low mag. (WC) | |||
Image:Dermatopathic_lymphadenopathy_-_low_mag.jpg | DL - low mag. (WC) | |||
Image:Dermatopathic_lymphadenopathy_-_intermed_mag.jpg | DL - intermed. mag. (WC) | |||
Image:Dermatopathic_lymphadenopathy_-_high_mag.jpg | DL - high mag. (WC) | |||
Image:Dermatopathic_lymphadenopathy_-_very_high_mag.jpg | DL - very high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
*Interdigitating dendritic cells: S100 +ve, CD1a -ve. | |||
*Langerhans cells: S100 +ve, CD1a +ve. | |||
==See also== | |||
*[[Lymph node pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Lymph node pathology]] | |||
Revision as of 03:26, 10 December 2013
Dermatopathic lymphadenopathy is a rare pathology of the lymph nodes.
General
- Lymphadenopathy associated with a skin lesion - key feature.
- May be benign or malignant (e.g. T-cell lymphoma).
Microscopic
Features:[1]
- Abundant histiocytes & special histiocytes - in loose irregular clusters - located in the sinuses, i.e. sinus histiocytosis - key feature:
- Do not form granuloma; may be similar to toxoplasma.
- Plasma cells (medulla).
- Eosinophils.
Histiocytes & special histiocytes:
- Histiocytes:
- +/-Melanin pigment key feature (if present).
- Lipid-laden macrophages.
- Interdigitating dendritic cells:
- Need IHC to identify definitively.
- Langerhans cells:
- Classically have a kidney bean nuclei.
- Need IHC to identify definitively.
DDx:
- Metastatic malignant melanoma - (melanin) pigmented cells have nuclear atypia, not histiocytes.
- Sinus histiocytosis - no cells with melanin.
Images
DL - very low mag. (WC)
DL - low mag. (WC)
DL - intermed. mag. (WC)
DL - high mag. (WC)
DL - very high mag. (WC)
IHC
- Interdigitating dendritic cells: S100 +ve, CD1a -ve.
- Langerhans cells: S100 +ve, CD1a +ve.
See also
References
- ↑ Ioachim, Harry L; Medeiros, L. Jeffrey (2008). Ioachim's Lymph Node Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 226. ISBN 978-0781775960.