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Difference between revisions of "Nodular fasciitis"
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'''Nodular fasciitis''' is an uncommon [[soft tissue lesion]]. It should '''not''' to be confused with [[necrotizing fasciitis]]. | |||
===General=== | |||
*Benign. | |||
*All age groups. | |||
*Associated with trauma. | |||
===Microscopic=== | |||
Features:<ref name=Ref_WMSP606>{{Ref WMSP|606}}</ref><ref>{{cite journal |author=de Feraudy S, Fletcher CD |title=Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases |journal=Am. J. Surg. Pathol. |volume=34 |issue=9 |pages=1377–81 |year=2010 |month=September |pmid=20716998 |doi=10.1097/PAS.0b013e3181ed7374 |url=}}</ref> | |||
*Usu. well-circumscribed. | |||
*Clusters of (non-pleomorphic) spindle cells. | |||
*Inflammation (lymphocytes). | |||
*Microcysts in cellular regions - uncommon - ''discriminatory''. | |||
*Mitoses - common. | |||
*[[Extravasated RBC]]s. | |||
The BD feature list:<ref>Dickson, B. 26 April 2011.</ref><ref>URL: [http://anvita.info/wiki/Nodular_Fasciitis http://anvita.info/wiki/Nodular_Fasciitis]. Accessed on: 11 November 2011.</ref> | |||
*Tissue culture-like/CNS-like morphology. | |||
*Thick (keloid-like) collagen bundles - '''key feature'''. | |||
*[[Extravasated RBCs]]. | |||
*Inflammation. | |||
*+/-[[Giant cell]]s. | |||
Notes: | |||
*No significant nuclear atypia. | |||
*No atypical mitoses. | |||
*May be cellular. | |||
DDx:<ref>URL: [http://www.mckeedermpath.com/SPOT%20DIAGNOSIS%20CASE%20268.html http://www.mckeedermpath.com/SPOT%20DIAGNOSIS%20CASE%20268.html]. Accessed on: 11 November 2011.</ref> | |||
*Myxoid [[DFSP]]. | |||
*Cellular [[dermatofibroma]]. | |||
*[[Desmoid-type fibromatosis]]. | |||
===Images=== | |||
<gallery> | |||
Image:Nodular_fasciitis_-_intermed_mag.jpg | NF - case 1 - intermed. mag. (WC) | |||
Image:Nodular_fasciitis_-_high_mag.jpg | NF - case 1 - high mag. (WC) | |||
Image:Nodular_fasciitis_-2-_intermed_mag.jpg | NF - case 2 - intermed. mag. (WC) | |||
Image:Nodular_fasciitis_-2-_high_mag.jpg | NF - case 2 - high mag. (WC) | |||
</gallery> | |||
<gallery> | |||
Image:Nodular_fasciitis_%281%29.JPG | NF - low mag. (WC) | |||
Image:Nodular_fasciitis_%282%29.JPG | NF - high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.humpath.com/nodular-fasciitis NF (humpath.com)]. | |||
===IHC=== | |||
Routine spindle cell panel: | |||
*CD34 -ve. | |||
*Desmin -ve. | |||
*SMA -ve. | |||
*S100 -ve. | |||
*AE1/AE3 -ve. | |||
Others: | |||
*H-caldesmon -ve. | |||
*EMA -ve. | |||
*Vimentin +ve. | |||
===Molecular=== | |||
*Evolving - case reports. | |||
**t(15;15)(q13;q25).<ref name=pmid12606136>{{cite journal |author=Velagaleti GV, Tapper JK, Panova NE, Miettinen M, Gatalica Z |title=Cytogenetic findings in a case of nodular fasciitis of subclavicular region |journal=Cancer Genet. Cytogenet. |volume=141 |issue=2 |pages=160–3 |year=2003 |month=March |pmid=12606136 |doi= |url=}}</ref> | |||
==See also== | |||
*[[Fibroblastic/myofibroblastic tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Fibroblastic/myofibroblastic tumours]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||